1557-Reversible Epiblast Regionalization in Pluripotency
Scientific researchers have discovered that variability in the differentiation potential of human pluripotent stem cells (hPSCs) is driven by their epigenetic regionalization. Specifically, cells that fail to develop into brain organoids exhibit a posterior epiblast-like state characterized by the loss of bivalent chromatin marks and premature gene expression. To address this, the authors developed a chemical chromatin restoration (CHR) protocol that uses small molecules to reset the cells' internal programming. This treatment effectively shifts the cells back to a competent anterior state…
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