1539-Astrocyte CD40&MHC-II Presentation in CNS Autoimmunity
Recent research identifies a specific subset of astrocytes expressing CD40 and MHC-II that actively drive autoimmune responses in the central nervous system. Using advanced tools like RABID-seq and CRISPR-Cas9, scientists discovered that these glial cells function as non-professional antigen-presenting cells by interacting directly with CD4+ T cells. These interactions specifically amplify the activity of pathogenic TH17 cells, which are known to worsen conditions like multiple sclerosis and its animal model, EAE. The study further reveals that CD40 signaling triggers the accumulation of…
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