1395-Druggable Kinases in Neuropathic Pain Management
This review explores the potential of targeting protein kinases as a novel, non-opioid strategy for managing peripheral neuropathic pain. The authors categorize pain into central and peripheral types, specifically examining how conditions like diabetes and chemotherapy trigger debilitating sensations such as allodynia and hyperalgesia. By investigating several molecular targets, including p38 MAPK, AMPK, and EphB, the text illustrates how specific enzymes drive neuroinflammation and nerve degeneration. The source details various small molecule inhibitors, noting that while some drugs like…
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