How do our brains stay healthy as we age? | Tom Clandinin

From Our Neurons to Yours · Sep 25, 2026 · 42m

Today on the show, we explore the complex biology underlying a seemingly straightforward question: How do our brains stay healthy – or not – as we age?

There seems to be a constant flow of new secrets to healthy brain aging – inflammation, estrogen levels, how the brain clears out its waste. We've talked about many of these explanations on the show, and it can be easy to think that whatever the latest one is, that's the one. At least until the next one comes along.

In reality, each of those things is probably part of a larger complex system that guides brain aging. But if that's the case, how…