Using serum NFL and antibody titer to monitor disease activity in CASPR2/LGI1 autoimmune encephalitis

Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology · Sep 6, 2025 · 14m

This study explores the clinical significance of serum autoantibody titers and neurofilament light chain (NfL) levels in patients diagnosed with CASPR2/LGI1 autoimmune encephalitis. Researchers investigated these biomarkers longitudinally to understand their relationship with disease progression and patient outcomes. The findings indicate that NfL levels at the onset of the disease can predict long-term cognitive impairment, suggesting their utility in identifying patients requiring tailored management. While autoantibody titers correlate with disease stage and the occurrence of relapses…