Season 4 – Episode 2: The best time for a vaccine? Circadian rhythms and immunity
Is there a best time for a vaccine? In this episode of Light O'Clock, we speak with Dr Cathy A. Wyse about whether the time of day when we receive a vaccine can influence how we respond to it.
We first discuss how circadian rhythms shape the immune system, how vaccines work, and the difference between vaccine response (e.g., antibody levels) and vaccine effectiveness (i.e., protection against infection or disease). We then discuss why the current evidence remains mixed and how factors such as chronotype, sleep, age, sex, prior immunity, and vaccine type may influence results.
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