987-The Metaphyseal Niche Governs Leukaemic Stem Cell Fate

Paper Talk · May 17, 2026 · 22m

The research examines how the spatial positioning of leukaemic stem cells (LSCs) within different bone marrow regions fundamentally dictates their survival and disease progression. Studies using mouse models demonstrate that LSCs remain quiescent and stem-like when localized in the metaphysis, whereas moving to the central marrow induces cell-cycle activity and therapeutic vulnerability. This localization is controlled by a complex chemical signaling axis involving the enzymes DPP4 and GPC3, which regulate gradients of the chemoattractant CXCL12. Specifically, DPP4 deficiency or inhibition…