1376-Pathway Level Subtyping of Colorectal Cancer Phenotypes
This study introduces a novel classification system for colorectal cancer called Pathway-Derived Subtypes (PDS), which categorizes tumors based on biological activity rather than traditional gene-level data. The researchers identified three distinct groups: PDS1, which is highly proliferative and has a positive prognosis; PDS2, which is characterized by high immune and stromal activity; and PDS3, a newly discovered slow-cycling phenotype. Despite lacking unique histological patterns, PDS3 tumors demonstrate the worst clinical outcomes in locally advanced disease and are notably absent of…
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