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The Drug That Nausea Kept From Becoming a Psychedelic Mystery
The Drug That Nausea Kept From Becoming a Psychedelic Mystery
Nausea ended nearly every human trial before quipazine could show whether it was psychedelic - at 25 mg oral doses subjects had severe gastrointestinal distress, while rodents and monkeys showed clear LSD-like effects. How did a compound that substituted fully for LSD in animals fail so completely in people?
In this episode, we trace quipazine’s discovery in 1966, its pharmacological profile across serotonin receptors, and the contrasting human and animal data that left researchers baffled. Can the same molecule trigger vomiting…
The skinny
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