Latest / The Dr Louise Newson Podcast / 52 – Why psychiatrists must start thinking about hormones
Transcript
- 0:00Today on my podcast, I've got Doctor Gareth Jarvis, who is a
- 0:03psychiatrist who prescribes hormones.
- 0:06There's not many of those around.
- 0:07He's learnt a lot from his wife Rachel, who actually works with
- 0:10us in the clinic, and he talks about how important it is to
- 0:14think about hormones and mental health.
- 0:18Think about how important it is for us to be diagnosing properly
- 0:23in psychiatry and thinking about the important roles of hormones
- 0:27in our brains. So Gareth, thank you so much for
- 0:31coming today. It's always great having
- 0:35somebody who, like me, didn't really know about hormones at
- 0:39medical school and has just sort of seen the light almost.
- 0:43But you are a psychiatrist And I really enjoyed psychiatry.
- 0:49I did it in North Manchester with a very deprived area, but
- 0:53it was a really good unit, actually very cohesive.
- 0:57The, the doctors really worked together well.
- 0:59You know, my other students were really quite jealous that we
- 1:02were there in, in at the time we had eight weeks, which isn't
- 1:06long, but it is quite a good chunk of time compared to like
- 1:09one week of ophthalmology. I think that I did, but I've
- 1:12used a lot of my psychiatry training throughout, especially
- 1:15being AGP, but I never thought about the association of
- 1:20hormones and mental health. Whereas every day I think about
- 1:24it now. And you, you think about it more
- 1:26now, don't you? I do and I, I, I guess probably
- 1:31worth me saying Full disclosure right up at the top of the, the
- 1:34vodcast that my, my wife Rachel is AGP works for, for, for
- 1:37Newson Health. And she, she's amazing.
- 1:41And, and she's really helped bring me towards the evidence
- 1:45base around menopause. Because I'll admit, Louise, that
- 1:48I, I, I kept myself woefully poor, not up to date in this
- 1:52area for, for, for many years. It was, it was, it was a
- 1:56footnote at medical school when, when I was up there in
- 1:58Edinburgh, we, we maybe had a day on it.
- 2:00I do, I can't really. It's, it's so it's so much back
- 2:02in the midst of time now and through throughout my psychiatry
- 2:06training again, at best a footnote at any point was
- 2:09menopause discussed. And yet I, I, I look at it now
- 2:14and think, I can't believe that we haven't, we've done how
- 2:17little attention was paid to it throughout that, that time.
- 2:20I mean, if I, I look back at medical school, that was around
- 2:22the time that the, that the Women's Health initiative study
- 2:27was, was out. And so that, that message just
- 2:30came through of, oh, oh, hormones cause cancer and stay,
- 2:33stay away from them. It's HRT is dangerous.
- 2:35Was, was basically the only message I can remember receiving
- 2:38about it. And I don't think I'd really
- 2:41updated my knowledge since then because it wasn't my specialist
- 2:44area. It wasn't sort of specifically
- 2:48what what I was focused on within my training, though.
- 2:50I didn't have a single supervisor and knew about it or
- 2:53wanted to talk about it. And that's such a key part of
- 2:56how we train as medical professionals.
- 2:58You learn, you learn on the job a lot, don't you?
- 3:00And also what you read is dictated and shaped by your,
- 3:06like you say, your supervisors, your peers, any guidelines?
- 3:09So if it's, if it's not on your radar, it's really difficult,
- 3:12isn't it? And, and I, I mean, I trained
- 3:15before the WHI so I graduated in, in 1994 and then I became
- 3:20AGP in 2000. So the WHI study came out in
- 3:222002. But I was writing evidence based
- 3:25articles every week for GP magazines.
- 3:28It's a free magazine, went to every GP.
- 3:31So I wrote key, key topics in various things that I could
- 3:34choose. And actually I, I found them
- 3:36recently. So I, I wrote one on in 2001
- 3:39about HRT and then I wrote another series.
- 3:42I did 4 because he'd only had was a small column.
- 3:44And there's a lot to talk about obviously with hormones in 2002.
- 3:48And actually it's interesting because in 2002 I say, oh, this
- 3:51is study that's come out doesn't show us anything that we didn't
- 3:54know might be a slightly greater risk of breast cancer.
- 3:57But again, that's with older types of hormones, but but it
- 4:01definitely helps with bone protection, helps people feel
- 4:04better. And we can should continue, but
- 4:07obviously involve the patient in your decision making.
- 4:10But I was in my little GP practice then and I had no idea
- 4:14externally the rest of the world HRT prescribing had just fallen
- 4:17off a Cliff. And for, for, for the likes of
- 4:20you little bit younger, not having that anywhere in your
- 4:23radar. But when I was taught it was
- 4:26literally like you say a day or so, but it, or in a few hours
- 4:29really, but it was more about flushy sweat.
- 4:31So there's something it wasn't really nothing about the mentor
- 4:34house. And, and also, you know, as you
- 4:37know, well, Rachel, the scene, a lot of our patients have PMS and
- 4:41PMDD. And for those women actually, so
- 4:45premenstrual dysphoric disorder is about one in 20.
- 4:48So it's really common. And you know, patients say to me
- 4:52it's like light and day. You know, they they said as the
- 4:57light goes out, the whole personality changes those days
- 5:00before their periods. And I I must have seen it in
- 5:03general practice and psychiatry. But if you don't ask about a
- 5:07change throughout the cycle, and you only see the women in their
- 5:10crisis, if you like you, you don't build up the big picture,
- 5:14do you? And that's The thing is that so
- 5:17as psychiatrists, we're always trained to be really holistic in
- 5:20the way that we think about someone's health.
- 5:22And so, so we, we, and we've got the luxury of an hour to spend
- 5:26with someone really trying to understand fully what's going on
- 5:29with, with their lives. Can we actually figure out
- 5:32what's gone through the, the life course and that and that's.
- 5:34So what's so often one of the distinguishing features we're
- 5:36looking for is actually at what point in their life cycle did a
- 5:39change happen? But at no point was this sort of
- 5:43brought into my sort of thinking around actually focusing in on
- 5:45what, what happens on menopause. Yeah.
- 5:48You, you look at things that we, we, we know already about.
- 5:50So as we know in about for decades, when does suicide peak
- 5:53for women? It's between 45 and 54.
- 5:56And what's happening around that age.
- 5:58And, and I, I, I kind of almost sort of feel a little bit sort
- 6:02of shameful now sort of looking back of like, why wouldn't I
- 6:04have paid that more attention to actually focus in on the changes
- 6:09that happened for women at that time?
- 6:11And, and I, and I'm the same, but also when you read a stat,
- 6:14you don't always think what's behind it.
- 6:16And you might know that we've funded APHD student suicide
- 6:19prevention with Liverpool John Walls University.
- 6:22And she's just got her PhD and she's going to come and work
- 6:24with us actually full time in research, which is wonderful.
- 6:28And, and, you know, we've had some really interesting
- 6:31publications already about that, but also, you know, one of the
- 6:35publications, a lot of quotes from women whose lives we have
- 6:39saved with hormones. And one lady quoted to say, you
- 6:43know, if I had taken my life, I would just be another statistic.
- 6:47No one would have known I was perimenopausal.
- 6:50And this is a problem, of course, isn't it?
- 6:51And for many centuries, really, women have been dismissed and
- 6:57gas lit and, and being told, well, it's their stress, it's
- 7:01their circumstances. And I don't know if you know,
- 7:04but I was doing some volunteering in prisons.
- 7:06You know, a lot of people in prisons have a lot of mental
- 7:09health, all sorts of things that have gone on in the past.
- 7:13But they also, a lot of them have early menopause because of
- 7:18their drug abuse, because of what's gone on in the past, you
- 7:21know, and a lot of them are on heavy duty psychiatry drugs.
- 7:25So a lot of them are on quetiapine, a lot of them are on
- 7:29pregabalin and gabapentin, some of them are on lithium, a lot of
- 7:34them have implants for contraception.
- 7:37And the reason I'm saying all these drugs is because they will
- 7:39not have their own natural hormones in their body.
- 7:41So a lot of them have physical symptoms.
- 7:43So a lot of them were having very itchy dry skin, a lot of
- 7:46cystitis, urinary tract symptoms, palpitations, and they
- 7:50weren't having periods. So I was going just to educate
- 7:54about what hormones are and do talking to some of the younger
- 7:57ones about PMDD because we've known for many years people are
- 8:01more likely to commit a crime when they're angry and irritable
- 8:04these days for the periods. And a lot of them, it was a
- 8:07light bulb moment and they were like, Oh my goodness, that's me,
- 8:10that's me. But they couldn't get access
- 8:13hormones from their GPS or the, the doctors in, in, in prison.
- 8:18And, and I actually got reported to someone in the prison service
- 8:21because the doctors weren't happy I was there.
- 8:24And they reported me to my responsible officer who does my
- 8:27appraisal. And they said that I was saying
- 8:30that all mental health was due to hormones.
- 8:34And like, it's just crazy because it's so many things that
- 8:38affect our mental health. Absolutely.
- 8:40But if we ignore hormones the whole time, we're never going to
- 8:44get people completely well, I don't think.
- 8:46That's it for me is that I'm, I'm not going to sort of turn
- 8:49around and say that HRT is some kind of silver bullet for all
- 8:52mental health problems, but we cannot ignore it.
- 8:56It's such an integral part of, of a woman and making sure that
- 9:01she's optimised health. That's, and it has such a big
- 9:04impact on mental state that, that, that why on earth would we
- 9:08not be exploring that and being curious about it and, and, and
- 9:11actually making sure we, we, we've got these incredibly low
- 9:15risk things that we can prescribe now for, for, for,
- 9:18for, for, for someone who's in their perimenopause or menopause
- 9:22and they've got all these other massive health benefits.
- 9:25I mean, it's one of the things that really capture my
- 9:27imagination, as I've been talking with Rachel about it, is
- 9:29that we've known for a very long, in that time now this
- 9:32enormous mortality gap we have for people with severe mental
- 9:36illness, It's 20 years and younger that you will die if you
- 9:40have a, on average, if you have a severe mental illness.
- 9:43And what are they dying from? They're dying from
- 9:45cardiovascular disease. They die from strokes, they die
- 9:47from dementia, they're dying from cancer.
- 9:50And what are all the what, what if we're looking around what's
- 9:54in our armament to really sort of try and push back about that
- 9:56holistically as as doctors working with people from
- 10:01whatever background they're coming from in medicine to help
- 10:03close that mortality gap. This is feels like such a potent
- 10:08tool to have in the box to actually support women with
- 10:10making sure that their bones stay strong and healthy, that
- 10:12their cardiovascular systems protected, that their brain is
- 10:15protected. Why wouldn't we be prescribed?
- 10:17Well, it's so interesting and I'm, I'm very interested in the
- 10:20immune regulating effects of hormones because I don't know if
- 10:24you know, I've got a pathology degree as well.
- 10:26And I spent the whole year focusing on the macrophage and
- 10:31inflammation. And the more we look at that
- 10:34neuro inflammation, so inflammation in the brain, it
- 10:37does seem to be closely associated with mental health,
- 10:40schizophrenia, depression, bipolar.
- 10:43And you know, we know that inflammation is associated with
- 10:45cardiovascular disease, osteoporosis, dementia.
- 10:49So there is a link as well, which we can't keep ignoring.
- 10:53But I'm also, I'm interested in pathology, but I'm also
- 10:56interested in history because I think that can shape a lot
- 11:00actually, especially in medicine.
- 11:02So thinking about the power of hormones in our brain, we've
- 11:05known for many years. I mean, we've only known about
- 11:07hormones since the 1930s when they were discovered.
- 11:11But even in the Victorian times before that time, there were
- 11:14lots of people going to asylums, as we know.
- 11:16But there were some really great writers of someone called Edward
- 11:19Tilt who wrote in great book in in 1888, which I've read and
- 11:25talking about the change of life, and he was talking about
- 11:28this this time. That was a real toll on mental
- 11:31health that seemed to improve with bleeding.
- 11:36So he didn't know about hormones, but he knew there was
- 11:38something that was going on. And he did talk about people
- 11:41going to prisons and committing crimes because of these
- 11:44symptoms. He talked or he wrote a lot
- 11:48about the toil of looking after children, the women, the mental
- 11:53health, you know, and, and he was alluding to it being around
- 11:56the cycle, you know, and I think then they didn't have the drugs
- 12:00that we have now. They weren't so short for time
- 12:03as we are often now. So he could really, really
- 12:06explore with patients and he was really associating the physical
- 12:11symptoms and the mental health symptoms.
- 12:15And then they discovered hormones, commercialized them
- 12:17and they went off down a different track.
- 12:19But then also the antidepressants and
- 12:21antipsychotics came out and so a way of getting people out of the
- 12:25asylums was just giving them the antipsychotics, wasn't it?
- 12:29To clear the to clear the asylums.
- 12:31And these these people maybe got better temporarily, but then
- 12:35they realised the side effects of the antipsychotics.
- 12:37And, and this is The thing is that that it's, I've, I've
- 12:41always been someone within psychiatry who's cautious about
- 12:44the prescription of, of, of psychotropic medication.
- 12:46Now it that they are really important efficacious treatments
- 12:52that we have, however they are they're patents and they come
- 12:57with with side effects. And so they have to be used to
- 13:00just judiciously and carefully and fit for the right situation
- 13:04and for the shortest period of time that we can for somebody.
- 13:07And for, for me now when I sort of, I, I look at a woman coming
- 13:13to my clinic and we're going through the history, I do want
- 13:16to stop and think about actually, if you're already on
- 13:18HRD, have we optimized it? Because there's, there's so much
- 13:22variation in the practice of its prescription because actually
- 13:25giving a woman back her own natural hormones, Why wouldn't
- 13:27we go there first before we start introducing a, a
- 13:33psychotropic medication into the system?
- 13:37It's it just feels not like. You know, if I said to you,
- 13:40look, you've got an iron deficiency and you're quite
- 13:43tired, Yeah, tiredness is a symptom of depression.
- 13:46But I wouldn't give you an antidepressant.
- 13:48I would try you an iron first, yes.
- 13:49Yes, yes. It's it's all quite simplistic
- 13:52medicine, isn't it? And, and the same, you know, we
- 13:55know that progesterone, estradiol, testosterone are made
- 13:58in the brain. They're newest do, yes.
- 14:00So they have a role in the brain.
- 14:01And, you know, there was, there's even randomized control
- 14:05studies from the 1980s, women with severe mental illness who
- 14:09are in a psychiatric hospital given either placebo or estudiol
- 14:15in conjunction with their other medication.
- 14:17And the results are staggering. Thanks so much for listening to
- 14:23my podcasts. Did you know that if you prefer
- 14:25to watch rather than just listen, my podcasts are
- 14:28available on YouTube every week. You'll find full episodes and
- 14:32additional educational content on my hormones, menopause and
- 14:36Women's Health, all grounded in science and real clinical
- 14:39experience. It's another way for me to share
- 14:42evidence based information, challenge outdated thinking, and
- 14:46make complex topics clearer and more accessible.
- 14:49So if you want to stay up to date, revisit episodes or share
- 14:53them with others who might benefit, make sure you subscribe
- 14:56to my YouTube. But the other thing about
- 15:00antipsychotics that I I never realised because I didn't think
- 15:05too broadly that antipsychotics affect metabolism.
- 15:09So we know that people on them long term, there's an increased
- 15:12incidence of heart disease, diabetes.
- 15:15People usually have the blood tested for their cholesterol,
- 15:19they have their blood pressure quite rightly done, but we know
- 15:23that they can increase prolactin.
- 15:25So if they increase prolactin they can switch off or suppress
- 15:28FSH and LH2 hormones in our brain.
- 15:31So basically give people a chemical menopause.
- 15:33We've known for many years that people on these antipsychotics
- 15:36long term have amenorrheas, a stopping of periods.
- 15:40But I've been trying to work out guidelines and I've been in
- 15:43touch with your Royal College of Psychiatrists in case I've
- 15:45missed them. But they've confirmed to me
- 15:47there aren't guidelines that we have to be testing or
- 15:50psychiatrists should test for hormones in women who are on
- 15:54psychiatric medication long term.
- 15:55And it doesn't make sense really.
- 15:57Absolutely. I, I think this is where we get
- 15:59into some of the barriers that, that, that are there for
- 16:01psychiatrists in trying to sort of their, their, their practice
- 16:05and stepping into thinking about perimenopause, menopause.
- 16:10I know as an, as an NHS consultant that it can be really
- 16:13challenging to do blood testing as, as, as a, as a psychiatrist
- 16:17is. We're, we're often not well set
- 16:19up within the average psychiatry clinic to actually just turn
- 16:22around and say, oh, hang on, I'll just take a blood test off
- 16:24you. And we, we're quite often having
- 16:26to ask our GP colleagues to help assist us with that, or we're
- 16:30having to try and book in through one of our depot
- 16:32clinics. And it's complicated and
- 16:33challenging. So it's, it's so the systems
- 16:35just aren't really well set up for us doing blood testing on a
- 16:37regular basis. And I'm, I'm not meant to be an
- 16:39excuse, it's just a reality of it, isn't it?
- 16:42Because I know for my own practices, I've been starting to
- 16:44try and sort of build up the way that I'm working here.
- 16:48And, and I read more into the evidence and read more of the
- 16:50guidelines around how you can practice in this area.
- 16:52I sort of realise that, oh, I'd be really nice to actually know
- 16:54what the whole main levels are. So I've got a sense of, of, of
- 16:58where we're at. It's certainly inhibits me from
- 17:02wanting to go above the, the, the licence limits, even though
- 17:08I hear all the time from Rachel just how much success that she
- 17:11has within the Newson Health Clinic of actually knowing for,
- 17:14for women who are poor absorbers of estradiol that actually, if
- 17:18you've not had success in this sort of lower levels, it
- 17:20probably because they're a low, a poor absorb there.
- 17:23There was a CPD module that I completed a couple of years ago
- 17:27that so I noticed you, you assisted in writing the news,
- 17:29which, which is fantastic. I found that a really helpful
- 17:32module that's available on the Royal College website for, for
- 17:35our, our Co and CPD training. And that really got me over the
- 17:39line actually in feeling confident about prescribing
- 17:42because it just, it just really helped me understand exactly
- 17:45what. Yeah.
- 17:47All it actually did was reconfirm everything that I'd
- 17:49heard from Rachel before and had and had all the papers put in
- 17:52front of me by her. And we'd gone through and I'd
- 17:54read through a couple of the books.
- 17:55But actually then finally having the Royal College stamp on it
- 17:57helped get me over the line of feeling like, OK, I I feel
- 18:00comfortable and confident now that that my practice is being
- 18:02backed. Yeah, and I, I wrote that with
- 18:05some colleagues, but it took me a good two years because I got a
- 18:08lot of pushback to say surely the evidence isn't this good,
- 18:11Surely there's more but but fair play.
- 18:13And, and, and actually I paid some of our money so that it
- 18:16would be free access because it was really important for me that
- 18:20it was free access. And then I did get a, a prize
- 18:22because it was the most downloaded module and, and I
- 18:25went up to Edinburgh to, to receive it and which was great.
- 18:29And every psychiatrist I spoke to DSP realised this is problem.
- 18:33But most psychiatrists are not like you and they don't
- 18:35prescribe any hormones at all. And I find that really quite
- 18:40frustrating because as AGP, I'm expected to prescribe most
- 18:44things and hormones are safer than, yeah, most other drugs,
- 18:48you know? I I, I, I guess the, the, the
- 18:50thing for me that I, I, I've always been really lucky this,
- 18:53that I've had Rachel on tap this whole time.
- 18:55That, that, that who I, I, I can sit and debate cases with over
- 18:59the dinner table and, and then and just say, you need to
- 19:01describe that woman HRT. But but also that Rachel's she's
- 19:09given me permission to talk about this openly.
- 19:11Is that that that she's been going through her own
- 19:12perimenopause. And so we've had our own
- 19:15personal experience of sort of going through that journey and
- 19:19we we started to notice lots of changes with with with Rachel
- 19:22that she was, she was getting much more tired.
- 19:25She was, I mean, Rachel is just the most organised person you've
- 19:29ever met in your life. She's on top of everything all
- 19:31the time. And, and it just found that that
- 19:33we, she wasn't just quite on top of things the way she used to
- 19:35be. And then we started to find that
- 19:37there's lots of mood swings started coming in and there'd be
- 19:39these moments of explosive anger that would come out of nowhere.
- 19:42And I'd be thinking, Oh my God, what have I done now?
- 19:45And because I'm the kind of person who just internalised
- 19:47this stuff straight away. And I was thinking, oh, I'm, I'm
- 19:50a dreadful husband. I'm doing terrible things and,
- 19:53and, and it, and it starts to become this real sort of, it was
- 19:56a difficult point in our relationship where we were
- 19:59having these sort of flash points of, of argument.
- 20:02And then she started to really get, get into the, the world of
- 20:06understanding perimenopause and menopause and has been able to
- 20:10be prescribed. But she's a poor absorber and,
- 20:13and, and 100 microgram patch was not enough for her and she had
- 20:16to go up and, and she's on, she's on 400 micrograms now.
- 20:19So she she puts on 4 patches a day and.
- 20:22And, and, and that's been, that's finally got to the point.
- 20:24And it's a world of difference where, where and she, she, she's
- 20:28a she, she says, I've got my energy back.
- 20:30My mood is, is great again. I'm able to function.
- 20:35And so having, having that personal experience of and the
- 20:38confidence to see that, that, that that's made all the world a
- 20:43difference for her and, and for us.
- 20:46I, I, I think that's definitely made me want to go more.
- 20:49Women should have the chance to, to, to, to, to, to feel this.
- 20:52Good. And I mean it's the same.
- 20:54I mean I've been on HRT for 10 years, but I don't absorb well.
- 20:58And I was on 100 micrograms, it did nothing and going up to 200
- 21:02and I was perimenopausal then. So now I'm higher than that.
- 21:06But if I don't I it's I get migraines really badly anyway
- 21:10and they just get a lot worse and I get joint pain.
- 21:12But my mood was terrible at times.
- 21:14But I've I have managed to persuade a few psychiatrists to
- 21:18to prescribe. There was one of my patients.
- 21:21It's really sad actually. She was doing really well on HRT
- 21:24and then there was an HRT shortage a few years ago.
- 21:28So her GP said, well, you don't need it anymore so we'll stop
- 21:30everything. And her mental health
- 21:33deteriorated really quickly and her husband was doing some
- 21:37washing up and she, she jumped. So she fractured her, her spine
- 21:41and was in a psychiatric hospital.
- 21:43And he reached out to me and I went to go and visit her.
- 21:47Actually one Sunday. I just turned up at the hospital
- 21:51and I hadn't been to a psychiatric hospital for many
- 21:53years. And she was really agitated and
- 21:55she was absolutely mortified. I was there and she was like a
- 21:59little Sparrow, you know, she, she was, she wasn't one of my
- 22:03patients, so I didn't know what she was like before, but she was
- 22:05a clinic patient and I, I just felt really sad to see her.
- 22:08So she had very dry hair, very dry skin.
- 22:12She was ruminating a lot. She was fixating on the
- 22:14accident. She was so embarrassed that I
- 22:16was seeing her. So she had insight as well,
- 22:18which a lot of these people still do.
- 22:20And so I can't, couldn't prescribe for her because she
- 22:23was under the NHS. So I can't tune it.
- 22:25So the psychiatrist had done the module and, and recognized my
- 22:29name so agreed to prescribe for her.
- 22:33And I saw her as a review last week actually.
- 22:35And it's just amazing. She's, she's like, she's so
- 22:38well. But it's, it was the
- 22:40testosterone that made the biggest difference.
- 22:42And a lot of people who have that poorly, the estidine and
- 22:46progesterone help, but it's the testosterone and it takes time
- 22:49and, you know, physically she's looks completely different that
- 22:53mentally she's so different. And you know, it's, it's
- 22:58incredible. But having this rapport with a
- 22:59psychiatrist and actually giving them, telling them, you know, or
- 23:04advising them what would be good to prescribe, looking at the
- 23:07blood results with them, it's been really good.
- 23:09And it's happened to another couple of patients again, who
- 23:12have been inpatients. And that's really amazing.
- 23:15But I, I would have even thought about it years ago.
- 23:18That's what frustrates me. But now, now it's there, it's so
- 23:21obvious. And a lot of psychiatrists,
- 23:23well, we need more evidence. But actually there is really
- 23:26good evidence, yes. Compared even to some of the
- 23:29other drugs, Yeah. It's this sort of wilful
- 23:32blindness really, that they're using it as a a reason.
- 23:37Maybe, but but we need to change the conversations, don't we?
- 23:41And, and I found that a really tricky area to navigate.
- 23:43So Louise around it that, that relationship with other doctors.
- 23:46Yeah. And, and, and so even as I've
- 23:48sort of started making this a more regular part of my practice
- 23:51of prescribing HRT for women, after we've gone through
- 23:53figuring out that that feels like a right fit for something
- 23:55to try. And then we've had some amazing
- 23:57results where, where, where women have just come back and
- 24:00said, I feel this has really helped.
- 24:03You know, it's not sold my probably because, but by the
- 24:05time they come to see me as a, as a psychiatrist, they, it's
- 24:07usually, it's usually pretty severe and complex mental health
- 24:11problems because actually the vast majority of mental health
- 24:13problems is managed by general practice, of course.
- 24:15And, and, and so I'm seeing the most severe end.
- 24:17So it's not, as I say, not some silver bullet that's just taken
- 24:19away their, their, their problems.
- 24:21But they said this has helped. I'm sleeping better.
- 24:23I'm not drenched in sweats. I, my, my mood just feels that
- 24:26little bit calmer and I'm just able, I've got that energy back
- 24:29to sort of start doing things again.
- 24:31So I'd really like, you know, we said, great, let's get it
- 24:33continued And I'll write back to the GP and say, you know, we've,
- 24:35we've done this trial of HRT, please carry it on.
- 24:37And I've had some very rude letters back from, from, from
- 24:40some GPS where, where they've actually come back and said,
- 24:42what do you think you're doing as a psychiatrist, right?
- 24:44They're prescribing HRT or another one I had was, was a
- 24:49woman who'd, she'd had a hysterectomy and she'd been
- 24:53given some HRT, but it was a very, it was, it was 50
- 24:55micrograms of, of estudiol and that was it.
- 24:59And we said, I said, well, do you know what?
- 25:01Actually, I, I think if we add in some mute suggestion because
- 25:04she was really complaining that her sleep was really poor and
- 25:07she's very anxious. I said, I, I just, I'm
- 25:09interested to find out if this would be helpful.
- 25:11And and this is this is common practice when the psychiatry in
- 25:14terms of trying things out. Because they used to therapeutic
- 25:16trials. Because what the medications we
- 25:19prescribe normally in psychiatry that, that it's not like we're
- 25:21topping up your lack of sertraline or, or whatever it
- 25:25might be. And we're, we're, we're, we're
- 25:27adding into the agents the body doesn't normally have because
- 25:30we're trying to see if if the effects of it are helpful or not
- 25:33and give some space for helping. So, so that's just normal way
- 25:36that we practice in psychiatry. So I think if you can enter into
- 25:39HRT prescribing in that spirit of let's try something and, and,
- 25:43and again, just want to re emphasise that very low risk.
- 25:47So, so why wouldn't we give it a go?
- 25:50Because you can always not prescribe it again.
- 25:52If actually it turns out that that that did nothing or, or,
- 25:54or, or you can, we can play with it a bit more and try and see if
- 25:57we can find it even better fit. But yes, so it's so right.
- 25:59Back to that story, ladies had a hysterectomy.
- 26:02We introduced some neutrogestan. And yes, after a few weeks, you
- 26:06know, she came back a few weeks later and said, do you know what
- 26:08that actually really helps? I, I'm, I'm sleeping a lot
- 26:10better. I feel a bit calmer.
- 26:12I'd like to continue that. I was like, great.
- 26:14So we wrote back to the GP and said that, you know, we've
- 26:17increased these style. We've we've prescribed to me
- 26:19from you to dress down. And she, she came back and said,
- 26:22well, she doesn't need you to dress down.
- 26:24She hasn't got a womb. And so, so, so I then entered a
- 26:28bit of a back and forth in the emails saying, well, actually,
- 26:31you know, she's, she's benefiting from it.
- 26:33And we know that progestion has an effect on the GABA system
- 26:36thanks to your module. And, and and that's, that's
- 26:40going to reduce anxiety, it's going to help with the sleep.
- 26:44So why on earth wouldn't we continue that?
- 26:47And she then came back again and, and, and, and I did have to
- 26:52send us quite a few more materials and papers to sort of
- 26:54try and reassure 'cause you should come back saying it's
- 26:55gonna give her blood clots. And so it's just, there's no
- 26:58evidence for that. And, and it's amazing the amount
- 27:01of misinformation that's out there.
- 27:03And, and I and I feel like there's no other area of
- 27:04medicine that has this degree of misinformation no in it.
- 27:08It's absolutely madding, isn't it, Because we're arguing over a
- 27:11natural hormone at the end of the day and the patient is
- 27:15central to that decision making process.
- 27:18And, and actually we are reaching a stage often where the
- 27:20patients know more than the doctors.
- 27:22And that can be difficult. But a lot of doctors are, are
- 27:25waking up and realizing because it is basic Physiology as well.
- 27:29And you know, we can, we can have the psychiatric medication
- 27:33alongside. It's not a one or the other.
- 27:35And often the, you know, people need both.
- 27:37That's fine as well. So there's lots we need to do
- 27:40and I'm just really grateful that you're here talking about
- 27:43it and hopefully we'll we'll change the minds of others.
- 27:46Well, do you know that that thing about changing minds is it
- 27:49occupies me a lot because it's, so as a psychiatrist, I, I'm
- 27:53really passionate about an approach to mental health care
- 27:56called open dialogue, which is really inclusive of family and,
- 28:00and trying to be transparent with the people that you're
- 28:02working with. So, so it's just got the
- 28:04effectiveness, it's heart, it's that, it's, it's making sure
- 28:06that you have all the conversations you need to have
- 28:08about someone in front of them and that you include their
- 28:11social system around them or anyone who's important to them.
- 28:14And, and I've been working on that for about 10 years now with
- 28:18various people in the UK. And we've been did a big
- 28:20research trial around it called a Desi that we're publishing
- 28:22soon. And it's, it's amazing the
- 28:27amount of resistance I've had over that time of trying to
- 28:31bring in a different way of working that that that there's
- 28:35just this huge degree of conservatives, small see
- 28:38conservatism amongst the medical profession to anything that's
- 28:40new or different, this sort of level of suspicion.
- 28:43Yes, it is. Suspicion isn't.
- 28:45It of, of, of just, you know, that, that, but I, I, it's
- 28:49amazing the sort of range of responses I'll get to it when I
- 28:52start trying to explain. There's this sort of way of
- 28:53working to, to, to people. The first of all, they go, oh,
- 28:55that's no different to what I do already.
- 28:58And then the next response is, oh, when they really get to
- 29:00understand, they go, that's too radically different from what we
- 29:02do already. Then it's almost too expensive.
- 29:05And no, it'll take too much time and, and every excuse in the
- 29:08book will come out and be thrown in the way of anything but
- 29:11trying to embrace change. And I know we, we, we, we love
- 29:16our old stories of medicine. And I and I often think about
- 29:19the the story of Semmelweis. Oh yeah, the.
- 29:22The, the, the Hungarian obstetrician who, who, who the
- 29:27medical students were coming in from, from the anatomy lab and
- 29:30they were, and they weren't washing their hands and they
- 29:32were going, helping out deliver women's babies.
- 29:34And, and, and he could see on the, the, the ward where the
- 29:37medical students were delivering babies rather than the ones
- 29:39where the the the midwives were that they had much high
- 29:41mortality rate. And presenting that data to to
- 29:44his colleagues, he got utterly ostracized.
- 29:46He wasn't allowed to. Well, he wasn't allowed to
- 29:48conferences. But the worst, saddest thing
- 29:50about Semmelweis is that he ended up beaten to death in a
- 29:53straitjacket. And in an asylum.
- 29:55In an asylum and, and don't be wrong, I mean, there's many
- 29:57times that I've thought about Semmelweis and thought about my
- 30:01own mental health. But we need to end on a happy
- 30:04note and things are changing and people are learning and we, you
- 30:08know, we need to keep looking at the evidence.
- 30:11We need to keep looking at basic neurophysiology because that's
- 30:15often what we're talking about. South three things, Gareth, that
- 30:19think, what three things do you think psychiatrist should just
- 30:23know about hormones? I'm not saying about
- 30:25prescribing, but just know so they can ask the right questions
- 30:28for their patients. I'm so three things.
- 30:34So the first thing I would say, I would really strongly
- 30:39recommend the CPD module on the raw college websites.
- 30:43It's really straightforward and you can get it complete within
- 30:47an hour or so and it will just bring you right up to speed
- 30:50really quickly. So I think show there, secondly,
- 30:54I would think about how you can start having these conversations
- 30:59with your, your, your, your patients in your clinic of
- 31:02actually just being curious, being curious about that life
- 31:05cycle and thinking about when did this change happen?
- 31:09And is this woman in that sort of age range of sort of 35 to
- 31:1355, somewhere in that range of actually what should I be
- 31:16thinking? Hormones and the third one, we
- 31:20we'd be, don't be afraid to prescribe.
- 31:23You've got, you've got these really low risk natural products
- 31:26that you can prescribe to women, their own hormones that you can
- 31:29give back to them. And it's it's going to be part
- 31:34of the solution not just for their mental health, but you're
- 31:36going to be promoting their physical health as well, which
- 31:38is such a core issue for us to drive forward.
- 31:40Yeah, so important. So thank you so much for sharing
- 31:43your wisdom and thoughts today. Thank you.
- 31:46Thank you, Louise. I've got something really
- 31:50exciting to share with you. Every Thursday I'm going to be
- 31:53releasing an extra episode for those of you that sign up.
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- 32:11research that's away from pharmaceutical companies.
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