1090-Temporal Architecture of Seminiferous Epithelial Cycle

Paper Talk · Jun 6, 2026 · 21m

This research utilized spatial transcriptomics to map the complex temporal and physical organization of spermatogenesis in mouse testes. By analyzing nearly 900,000 cells at single-molecule resolution, the authors reconstructed the seminiferous epithelial cycle, identifying a circular transcriptional topology that governs tissue timing. A major discovery is that Sertoli cells possess an intrinsic oscillatory program that persists even when germ cells are absent. The study identifies retinoic acid as a vital permissive signal for this cycle, while paracrine cues like Wnt signaling help refine…