Latest / Skin Anarchy / Longevity Science Is Taking Front And Center On The Skin Health Stage ft. novos

Transcript

Longevity Science Is Taking Front And Center On The Skin Health Stage ft. novos · Skin Anarchy

• 0:00
  SPEAKER_00: This episode is brought to you by Vonage.
• 0:02
  SPEAKER_00: Your business needs more than an 800 number.
• 0:04
  SPEAKER_00: With Vonage Voice API, you can provide the call experience your customers expect and get the data your team needs.
• 0:10
  SPEAKER_00: From call analytics and virtual assistance to automatic speech recognition and text-to-spee in multiple languages.
• 0:16
  SPEAKER_00: Your customer service team can help more people in more places.
• 0:19
  SPEAKER_00: And with Internet Voice, your customers can easily contact you the moment they have a question.
• 0:23
  SPEAKER_00: Take your calls to the next level with Vonage Voice API.
• 0:27
  SPEAKER_00: Learn more at Vonage.com.
• 0:31
  SPEAKER_03: Level 4 has arrived.
• 0:33
  SPEAKER_03: As the forces are held gathered, only you can stand in their way.
• 0:37
  SPEAKER_03: Journey across the expansive open world sanctuary.
• 0:40
  SPEAKER_03: Choose from five powerful classes that progress them to figure play style.
• 0:45
  SPEAKER_03: Adventure with your permanent enough to four-player co-op with cross-play and cross-progression on the platforms.
• 0:50
  SPEAKER_03: Welcome to Hell Double 4.
• 0:53
  SPEAKER_03: Available now, rated and premature.
• 0:55
  SPEAKER_03: Have the banner or visit this episode's page to learn more.
• 1:01
  SPEAKER_01: This episode is brought to you by ReliefBand.
• 1:04
  SPEAKER_01: If you regularly suffer from nausea, listen up.
• 1:07
  SPEAKER_01: ReliefBand is a clinically proven wearable nausea solution with no drugs or unwanted side effects.
• 1:12
  SPEAKER_01: It treats nausea caused by motion sickness, anxiety, migraines, and more using technology that sends signals to your brain to stop nausea quickly and effectively.
• 1:21
  SPEAKER_01: Get relief today.
• 1:22
  SPEAKER_01: Shop now at reliefband.com.
• 1:25
  SPEAKER_01: And to get 20% off your purchase, use the code RELIFE20 at checkout.
• 1:49
  SPEAKER_02: This is your host, Ecta, and today's episode is very, very special to me because I am really excited to learn all about this phenomenal brand.
• 1:59
  SPEAKER_02: As many of you know, we are in the space right now, as far as the beauty industry goes and the wellness industries go, where um aging well and log longevity science is really taking over and it's taking um, you know, front and center positions.
• 2:15
  SPEAKER_02: So without further ado, I want to introduce you guys to the founder of a revolutionary new brand that I discovered.
• 2:23
  SPEAKER_02: Um thanks to Jan Marini.
• 2:25
  SPEAKER_02: Huge shout out to Jan for putting me onto Novos.
• 2:28
  SPEAKER_02: Um but without further ado, uh welcome Chris Miraboli, founder of Novos.
• 2:32
  SPEAKER_02: Welcome, Chris.
• 2:33
  SPEAKER_04: Thank you, Ecta.
• 2:34
  SPEAKER_04: It's nice to be here.
• 2:36
  SPEAKER_02: It's lovely to host you.
• 2:37
  SPEAKER_02: And like I said, you know, I'm already a huge fan of the brand and can't wait to learn all about it.
• 2:42
  SPEAKER_02: But I really want to learn about you first and your background and what led to you know your work with Novos.
• 2:48
  SPEAKER_02: If you could walk us down memory lane.
• 2:50
  SPEAKER_04: Sure, sure.
• 2:51
  SPEAKER_04: So it begins when I was 12 years old.
• 2:54
  SPEAKER_04: I was really interested in health.
• 2:56
  SPEAKER_04: I saw an issue of Men's Health magazine on the newsstand, and uh I was inspired by the people in the magazine.
• 3:03
  SPEAKER_04: So I started to exercise and eat healthy.
• 3:06
  SPEAKER_04: And so uh, you know, compared to most other 12 and 13-year-olds, I was uh more healthy than most.
• 3:12
  SPEAKER_04: So it came as a real surprise to me when I was 16 years old and I was in New York City on a school trip when I suddenly felt dizzy and nauseous.
• 3:22
  SPEAKER_04: And the next thing I knew, I woke up with blood all over my shirt because I had had a seizure.
• 3:28
  SPEAKER_04: And when I was rushed to the emergency room, they later found out that it was caused by a brain tumor.
• 3:35
  SPEAKER_04: And so uh the next steps were emergency surgery and radiation and removal of that tumor, and then about a year worth of recovery and all that time it really shaped me in in so many different ways.
• 3:47
  SPEAKER_04: I was contemplating mortality at 16 years old and in a position where I never wanted to be again until like the very, very final days, hopefully far out into the future.
• 4:00
  SPEAKER_04: So that that really evolved my thinking of health from one that was much more superficial, admittedly.
• 4:07
  SPEAKER_04: Like when I was a teenager, I just wanted to be attractive and and play sports well.
• 4:11
  SPEAKER_04: And so I wanted to build muscle and um and uh and that's that's more of the aesthetic side of health.
• 4:18
  SPEAKER_04: But after this experience, I realized that health is far more than that, it's biology, it is the avoidance of disease.
• 4:25
  SPEAKER_04: And so that was was a seed that was planted that has over the years eventually uh blossomed into what I've now started with novos.
• 4:35
  SPEAKER_02: That's wow, what a story.
• 4:37
  SPEAKER_02: I I'm so sorry that you had to go through that first of all at such a young age, but I am so happy to see that not only did you come through, but now you're doing something so incredible um with your time and your work.
• 4:48
  SPEAKER_02: I mean, really hats off to you, Chris.
• 4:50
  SPEAKER_02: That's that's very inspiring.
• 4:52
  SPEAKER_04: Thank you.
• 4:53
  SPEAKER_04: Thank you.
• 4:53
  SPEAKER_04: That's very kind of you.
• 4:55
  SPEAKER_02: No, I mean, I I really want to learn all about the brand, um, you know, really, because the idea of this aging, you know, like aging well, right?
• 5:04
  SPEAKER_02: It's it's almost, you know, treated as this novel uh approach now in the cosmetic industry.
• 5:11
  SPEAKER_02: And I always find it to be a little strange, you know, from a scientific standpoint, where you know, I kind of grew up with science and and seeing how we definitely don't propagate anti-aging, you know, in general, and most scientists don't.
• 5:25
  SPEAKER_02: So when I found your brand, I was just so intrigued by how you guys were really um working with things like you know, focusing on telomeres and stuff.
• 5:33
  SPEAKER_02: So I want you to talk to us about that.
• 5:35
  SPEAKER_02: Talk to us about like what does novos really stand for and what is the approach you're taking towards aging well.
• 5:42
  SPEAKER_04: Sure.
• 5:42
  SPEAKER_04: Yeah, what when uh scientists in the in the field of longevity medicine and longevity biology hear the term anti-aging, they kind of like shriek because it's it's not something that they they uh they believe in, the idea of of anti-aging, um, as opposed to longevity, longevity being trying to extend your health span and lifespan by as much as possible.
• 6:06
  SPEAKER_04: And in doing so, you could potentially slow down the aging process, which you know can in some sense lead you to that terminology of anti-aging, but not in the traditional sense.
• 6:20
  SPEAKER_04: When you think of cosmetics and and uh skincare products, it's typically just trying to hide the signs of aging by, for example, moisturizing your skin more.
• 6:30
  SPEAKER_04: Uh, whereas longevity would be taking the approach of trying to slow down the underlying biological mechanisms or causes of aging so that you are actually slowing down the aging process for your skin, but for your entire organ system, your your entire organism, if you will, um, as a whole.
• 6:52
  SPEAKER_04: So uh there's specifically 12 hallmarks of aging that scientists have uncovered.
• 6:59
  SPEAKER_04: And Novos as as a as a brand, as well as the flagship product that we sell, addresses all 12 of those hallmarks simultaneously.
• 7:09
  SPEAKER_04: We also include in our formulation, and since you brought up skin health, I'll I'll um talk a little bit to this.
• 7:15
  SPEAKER_04: Uh, there are ingredients that can have favorable impacts on skin health from the inside out.
• 7:22
  SPEAKER_04: So you can orally ingest these ingredients rather than applying them topically, and they can have positive effects.
• 7:29
  SPEAKER_04: Most people know of collagen by now.
• 7:32
  SPEAKER_04: Uh, there's also, for example, oral hyaluronic acid that can increase the hyaluronic acid in your skin and then thereby increasing the moisturization of your skin in the deeper uh uh layers of the dermis, um, as opposed to the topical solutions that are really on like the uh the top layers and the epidermis of the skin.
• 7:54
  SPEAKER_04: So these exist.
• 7:56
  SPEAKER_04: There will be more and more companies trying to create formulations that do this.
• 8:00
  SPEAKER_04: Where Novos is different is although we have ingredients that can have these short-term skin health benefits, we are once again we are focusing on the biological causes of aging as the foundation of the formulas.
• 8:15
  SPEAKER_04: So it's more about the long-term aging process, so that when you fast forward years from now or a decade from now, you have actually put the brakes on aging and you're doing far better than your peers.
• 8:28
  SPEAKER_02: That makes so much sense to me, honestly, Chris.
• 8:30
  SPEAKER_02: That's more practical than anything I've ever heard about it.
• 8:34
  SPEAKER_02: Because I mean, even with things like collagen, like you had brought up, like, you know, hyaluronic acid, collagen.
• 8:40
  SPEAKER_02: I mean, I'm always uh, you know, dealing with like supplement brands that want to, you know, come on the show or tell us about what they're doing.
• 8:48
  SPEAKER_02: But I always have this problem with understanding why people think that ingesting giant proteins that are not going to be utilized, you know, by the body is an approach towards, you know, doing what exactly you're talking about here, which is a whole different idea, right?
• 9:03
  SPEAKER_02: I mean, it's like people don't understand like molecular biology sometimes, I think, because that's not how things work.
• 9:08
  SPEAKER_02: You can't just take, you know, a giant collagen molecule and just think that it's going to go where it needs to go, you know.
• 9:14
  SPEAKER_02: So I have my own frustrations with that, I think, you know.
• 9:18
  SPEAKER_02: Um, but you had mentioned the 12 um pillars, right, of aging.
• 9:21
  SPEAKER_02: And I would love for you to walk us through those if you could.
• 9:25
  SPEAKER_04: Sure, sure.
• 9:26
  SPEAKER_04: So they're known as uh the 12 hallmarks of aging or the 12 mechanisms of aging in the scientific community.
• 9:33
  SPEAKER_04: Uh, shorthand, you could just say the 12 causes of aging, and they all they all uh connect with each other.
• 9:39
  SPEAKER_04: It's it's this complex web where they are all impacting each other.
• 9:44
  SPEAKER_04: Um so uh um I'll I'll go through each of them and I'll I'll just give a very quick summary of each of them for your listeners to uh understand from a high level what what each of these does.
• 9:54
  SPEAKER_04: So uh first is mitochondrial dysfunction.
• 9:57
  SPEAKER_04: And mitochondria are the power plants of our cells, they convert the carbs and the fats and the proteins that we ingest into energy.
• 10:06
  SPEAKER_04: And so as we age, the mitochondria they either die off, so you have fewer of them in each cell, or they become dysfunctional.
• 10:14
  SPEAKER_04: And if the power centers of your cells are becoming dysfunctional, then the cells can't behave as they should.
• 10:20
  SPEAKER_04: And then by extension, the tissue and the organ that they are a part of is not going to fully uh uh function as it should.
• 10:28
  SPEAKER_04: The second is cellular senescence.
• 10:30
  SPEAKER_04: So senescent cells are former healthy cells that stop dividing and they secrete substances that damage the healthy surrounding cells.
• 10:39
  SPEAKER_04: A lot of people think of senescent cells as zombie cells.
• 10:43
  SPEAKER_04: They have that type of characteristic.
• 10:45
  SPEAKER_04: They're not actually behaving as a healthy cell, they're also not dead and removed by the body.
• 10:50
  SPEAKER_04: So they just linger around and they release what's called a SASP, uh, which is this senescent associated secretory phenotype, a big term for a simple idea of just uh free radicals that can then damage nearby cells and could cause them to become senescent.
• 11:06
  SPEAKER_04: And uh um, and so you get more of these, they increase exponentially in number as you get older.
• 11:13
  SPEAKER_04: And so you want to try to reduce the amount of senescent cells and it plays a significant role in skin aging, actually.
• 11:20
  SPEAKER_04: Uh, number three is loss of proteostasis.
• 11:23
  SPEAKER_04: So over time, there's more and more proteins that accumulate inside and outside of our cells, which then interferes with proper functioning of those cells.
• 11:32
  SPEAKER_04: An analogy I like to give is if you think of uh you garbage accumulating inside of your home and outside of your home.
• 11:40
  SPEAKER_04: So you take the trash bags out, and now there's a ton of garbage by your driveway and your walkway, and there's garbage inside.
• 11:47
  SPEAKER_04: Now you can't access the features of your home.
• 11:50
  SPEAKER_04: Um, you can't even get into your home.
• 11:52
  SPEAKER_04: So it's very similar with a loss of proteostasis when the proteins build up.
• 11:57
  SPEAKER_04: Number four is altered intercellular communication.
• 12:00
  SPEAKER_04: So as we get older, our cells become increasingly exposed to a hostile environment, which is largely based on all of these different hallmarks of aging kind of conspiring together.
• 12:12
  SPEAKER_04: And it leads to an increase in inflammation, uh, more senescent cells, like I mentioned, dysfunctional stem cells, which we'll talk about in a moment.
• 12:21
  SPEAKER_04: Um, and so the cells are not able to communicate with each other as well.
• 12:26
  SPEAKER_04: When you think of our bodies, it's this like vast complicated network, uh, communication network, and molecules are secreted to be able to communicate uh to other cells.
• 12:38
  SPEAKER_04: And um, partly as a result of the loss of proteostasis and other reasons as well, um, the cells can't communicate with each other as well, and therefore they don't respond to stimuli the way they should, and um, and that leads to a negative environment.
• 12:55
  SPEAKER_04: Uh, number five is genomic instability.
• 12:58
  SPEAKER_04: So most people think of this as DNA damage.
• 13:01
  SPEAKER_04: And so DNA damage can be caused from all different sources.
• 13:05
  SPEAKER_04: It can be caused by UV radiation, which I'm sure you talk about all of the time.
• 13:09
  SPEAKER_04: Um, it can be caused by alcohol consumption or eating uh unhealthy foods.
• 13:16
  SPEAKER_04: So the body is fortunately able to repair DNA, but the more damage that occurs, uh the more likely it is that the body misses something and mutations take place.
• 13:28
  SPEAKER_04: And every time our DNA is damaged, our telomeres, which we'll talk about in a moment, they become shorter and more dysfunctional.
• 13:35
  SPEAKER_04: Um so I might as well just jump straight to telomere shortening.
• 13:39
  SPEAKER_04: So telomere shortening, we'll say that's number six.
• 13:42
  SPEAKER_04: Uh so the this is the um the ends of the chromosomes.
• 13:47
  SPEAKER_04: And the chromosomes are where our DNA um sits.
• 13:51
  SPEAKER_04: And so these these are like protective end caps of the chromosomes.
• 13:55
  SPEAKER_04: And every time our our cells are dividing, those telomeres get shorter.
• 14:01
  SPEAKER_04: And when those those telomeres get too short, then health consequences result.
• 14:06
  SPEAKER_04: For example, higher rates of gastrointestinal cancer if your telomeres are very short.
• 14:11
  SPEAKER_04: Now, um, if you have a mid mid-length or a long length telomere, you're probably in good shape.
• 14:18
  SPEAKER_04: Uh, and and the good thing is that telomeres are are something that you can actually um modify in a sense of you can increase their length with different dietary practices, with different supplements and and so on.
• 14:31
  SPEAKER_04: Um, number seven is epigenetic alterations.
• 14:35
  SPEAKER_04: So we talked about the the genes and DNA.
• 14:38
  SPEAKER_04: So the epigenome, an analogy I like I like to give is that if your genes are like a piano, the epigenome is like the piano player.
• 14:48
  SPEAKER_04: And it's essentially the expression of the genes, which genes are turned on and which genes are turned off.
• 14:54
  SPEAKER_04: And when we're young, our genes are uh epigenetically expressed in a in a very good way.
• 15:00
  SPEAKER_04: If you imagine like it's it's uh playing uh you know Tchaikovsky on on the keys, right?
• 15:07
  SPEAKER_04: And then if you fast forward to to you know the later years of your life, there are certain keys that you you press the wrong key or you accidentally miss a key or you add a key, and it it doesn't sound as good as it did before.
• 15:20
  SPEAKER_04: And so these alterations, these changes are detectable.
• 15:26
  SPEAKER_04: Um, and and there have actually been clocks um that have been created to measure people's biological age based on these patterns that emerge in the epigenome.
• 15:37
  SPEAKER_04: Um so number number eight, I think we're up to now, is uh deregulated nutrient sensing.
• 15:45
  SPEAKER_04: So as we age, our cells are less tuned to nutrient signals, which then disrupts their ability to produce energy.
• 15:54
  SPEAKER_04: So uh if you think of people as they get older, common um common symptoms of of age are, for example, higher blood glucose levels, less insulin sensitivity, higher levels of cholesterol and fatty acids and so on in the bloodstream.
• 16:12
  SPEAKER_04: And uh this this is as a result of the deregulated nutrient sensing.
• 16:17
  SPEAKER_04: Our bodies are not as sensitive to these molecules as they otherwise would be.
• 16:22
  SPEAKER_04: Uh, number nine is stem cell exhaustion.
• 16:25
  SPEAKER_04: So stem cells are are the cells that are producing replicas or copies of themselves to then uh you know uh uh maintain the health of our tissues and our organs, and they start to become dysfunctional as we age or they die off.
• 16:40
  SPEAKER_04: And so as a result, our tissues end up being less replenished and they're less well maintained.
• 16:46
  SPEAKER_04: Um, number 10 is is actually new.
• 16:50
  SPEAKER_04: So just a little bit of context.
• 16:52
  SPEAKER_04: The first nine were uncovered in a seminal paper in a journal called Cell almost a decade ago.
• 16:58
  SPEAKER_04: And it was a meta-analysis of hundreds of other studies where they looked at uh different causes of aging and then they categorized them and they categorized them into these nine hallmarks.
• 17:08
  SPEAKER_04: Those same authors of that seminal paper have created a new paper that was only published about two months ago.
• 17:15
  SPEAKER_04: And in this paper, they've identified three new hallmarks that they wanted to add to the original nine.
• 17:21
  SPEAKER_04: So these are these are well known and they've been studied well, but they're new in the context of um uh accounting them officially for uh biological causes of aging.
• 17:32
  SPEAKER_04: And so the first one of those is inflammaging.
• 17:35
  SPEAKER_04: So not inflammation, it's inflammaging.
• 17:38
  SPEAKER_04: To play on words, it's essentially a chronic low-grade inflammation.
• 17:43
  SPEAKER_04: Uh this this is inflammation that you know might be might be like a quiet whisper when uh when you're in your you know 20s or 30s.
• 17:51
  SPEAKER_04: And as every decade passes, it's it's increasing.
• 17:55
  SPEAKER_04: Um, an analogy I like to give for this is uh the whole boiling frog example of you know the frog sitting in a in a cool, tepid water pot, and then uh the temperature starts to rise slowly, gradually before it gets to the point that it starts to boil.
• 18:11
  SPEAKER_04: And um, and so inflammation or inflammaging is something that that we want to keep an eye on for aging.
• 18:17
  SPEAKER_04: Uh, number 11 is disabled autophagy.
• 18:20
  SPEAKER_04: So autophagy is a biological process in which um cells and and uh different components of cells are are absorbed.
• 18:33
  SPEAKER_04: Uh the body will will essentially eat those cells and eat those components and recycle them.
• 18:38
  SPEAKER_04: And as you age, the body is less capable of doing it and does it less so.
• 18:43
  SPEAKER_04: And then finally, uh the final one is dysbiosis or microbiome dysbiosis.
• 18:49
  SPEAKER_04: So there's been tons of research in the microbiome and how the microbiome can impact practically every other um organ system in the body.
• 18:57
  SPEAKER_04: Uh, we all heard by now about the you know gut-brain connection, but it goes well beyond just the gut-brain connection.
• 19:03
  SPEAKER_04: It goes um all over the place.
• 19:05
  SPEAKER_04: Uh, and so um as we age, the bacteria um changes and the the status of of the um the microbiome changes.
• 19:15
  SPEAKER_04: So, for example, maybe a more permeable gut, maybe more inflammation in the gut, maybe different bacterial species that are not as healthy start to emerge.
• 19:25
  SPEAKER_04: Uh and we we actually see in very long-lived people like centenarians that there's specific um microbial species, like for example, acromansia is one of them that increases dramatically as um as people get into the later um uh years of their life.
• 19:42
  SPEAKER_04: Um, that is the healthier people get into these later years of their life, um, but it's at very low levels when you're young.
• 19:49
  SPEAKER_04: And it's that very low levels when you're unhealthy.
• 19:52
  SPEAKER_04: So um those are all 12 if that wasn't enough.
• 19:56
  SPEAKER_02: Yeah, no, that was wonderful.
• 19:58
  SPEAKER_02: Thank you for that, because I I really wanted the audience to have this idea because you know, it's very important to really, you know, outline these um different 12 uh points that you addressed here.
• 20:11
  SPEAKER_02: Now, I do have some questions, and I and I would love to elabor for you to elaborate on a few of these.
• 20:16
  SPEAKER_02: Um, you know, what my biggest one, I think, you know, I I completely just it makes sense to me everything that you mentioned.
• 20:24
  SPEAKER_02: Uh, first of all, I want to say that it really does all work together.
• 20:27
  SPEAKER_02: And, you know, for everyone listening, it's it's good to have like a classification system where you're able to, you know, break down things into like these are the different things that are working to create this one response.
• 20:40
  SPEAKER_02: But there is this, you know, intrinsic mechanism in our body where everything does seem to work together at one point.
• 20:45
  SPEAKER_02: So, you know, with that being said, I really want to learn about, um, for example, you had um mentioned like autophagy, and then you mentioned the epigenetics and the loss of proteostasis.
• 20:57
  SPEAKER_02: I mean, all of this makes me think of like ubiquitination, right?
• 21:00
  SPEAKER_02: And like marking proteins to go get degraded or, you know, telling cells when they need to like be done, you know what I mean?
• 21:08
  SPEAKER_02: Like when apoptosis should occur.
• 21:09
  SPEAKER_02: So, like, what are some of the ways that Novos is targeting this from like a like a multifaceted angle, you know, in terms of just uh whether it's your formulation or whether it's your approach towards these molecular pathways?
• 21:23
  SPEAKER_02: I mean, has that been difficult or how like what's that whole experience been like for you um to to do that?
• 21:30
  SPEAKER_04: Sure.
• 21:30
  SPEAKER_04: So so let me uh give the audience a little bit more context and zoom out, and then we can zoom into your specific question.
• 21:37
  SPEAKER_04: So Novos has a company, we're a public benefit corporation.
• 21:41
  SPEAKER_04: Um, my my intention is to be able to help society at large, regardless of whether they're they're uh purchasing products from our from us or not.
• 21:49
  SPEAKER_04: And part of this is because of my experience with a brain tumor.
• 21:52
  SPEAKER_04: Um, another part of it is that um I I lost my mother while I was founding uh the company to pancreatic cancer and and I dedicated uh The company to her.
• 22:01
  SPEAKER_04: And so I want to do as much as I can to try to reduce the suffering.
• 22:05
  SPEAKER_04: Um, uh, while of course we are a for-profit business, and so we we do need to sell product.
• 22:10
  SPEAKER_04: So uh, with all of that said, uh we we've got three legs to the stool of Novos.
• 22:16
  SPEAKER_04: So uh one of those legs, and this is where we really shine for the public benefit, is in the form of information, knowledge that we share uh with with the public.
• 22:25
  SPEAKER_04: We we want to educate people about longevity, take the latest discoveries and innovations from the scientific lab and do that knowledge transfer in a comprehensive way for the consumer to be able to understand it without dumbing it down.
• 22:40
  SPEAKER_04: We our our content is is written by MDs and PhDs uh and scientifically referenced, but also something that is comprehensive for um uh the average person or the sophisticated person to be able to learn from.
• 22:56
  SPEAKER_04: Uh, and so you can find that on our website, nobleslabs.com on the blog section.
• 23:01
  SPEAKER_04: Um, we also have webinars that we host where we we dig into topics and you can watch videos of those on YouTube.
• 23:09
  SPEAKER_04: Um, and so that's that's the first leg.
• 23:11
  SPEAKER_04: The second leg is testing.
• 23:13
  SPEAKER_04: And for testing, there are free things we can do.
• 23:16
  SPEAKER_04: We offer a uh questionnaire on the website that gives you a longevity score.
• 23:20
  SPEAKER_04: This this is based on uh scientific studies and your lifestyle and family history, and it can then give you a score as to how well you're doing for longevity.
• 23:30
  SPEAKER_04: Uh, it's it's important to note that 90% of your longevity, so your health span and your lifespan is due to lifestyle, and only 10% uh is due to your um your your genetics.
• 23:44
  SPEAKER_04: So that's really important for people to keep in mind.
• 23:46
  SPEAKER_04: It's not all in the genes, it's far less than most people think.
• 23:49
  SPEAKER_04: And where it tends to become more important is when you're looking at people who are living to 110, 120 years old.
• 23:55
  SPEAKER_04: Uh, but for most of us uh to live to 90, 100 years old, it's predominantly lifestyle.
• 24:01
  SPEAKER_04: Um, a second test we offer for free is something called Face Age, where it uh your your audience might be particularly interested in this.
• 24:08
  SPEAKER_04: It's a facial AI tool uh that that we pay for, but we give it for free to our um to the general public.
• 24:16
  SPEAKER_04: You take a selfie and it will, based on a data set of 12 million people, it will tell you how old your face looks, um, your facial eye score like eye bags and so on, your skin health like wrinkles, um uh inflammation in the form of redness, pore size, and so on.
• 24:36
  SPEAKER_04: And then, of course, we don't leave you with that.
• 24:38
  SPEAKER_04: We give you then articles and content to um give you guidance on how to improve all of these different scores.
• 24:45
  SPEAKER_04: Um, and then we also have a a uh product that we sell, which is called Novos Age.
• 24:51
  SPEAKER_04: This is an epigenetic test.
• 24:53
  SPEAKER_04: I mentioned the epigenome before.
• 24:55
  SPEAKER_04: It looks at your epigenome and it tells you your pace of aging, your biological age, and your telomere length.
• 25:02
  SPEAKER_04: So basically, uh two of the hallmarks are accounted for in the form of the epigenetics and the telomeres in this test.
• 25:09
  SPEAKER_04: And uh it's it's not our own test, admittedly.
• 25:12
  SPEAKER_04: We license it from Columbia University and Duke University.
• 25:15
  SPEAKER_04: Um, we did so because we firmly believe this is the most powerful test in the world for biological age.
• 25:21
  SPEAKER_04: There are many companies coming out with them now.
• 25:23
  SPEAKER_04: Some are saliva tests, we're a blood test, uh, which is superior to saliva tests.
• 25:28
  SPEAKER_04: Um, there are 45 studies uh published at 30 different labs across the world investigating the tests that we we share.
• 25:36
  SPEAKER_04: So it's very open in the scientific community, whereas other companies have their own private black box solution with really no scientific validation.
• 25:44
  SPEAKER_04: Um, so for a number of reasons, we believe this is the best one, and and we offer that to consumers to really track your pace of aging.
• 25:51
  SPEAKER_04: It's kind of like the equivalent of a scale for a weight loss journey.
• 25:55
  SPEAKER_04: This is uh for your longevity journey.
• 25:58
  SPEAKER_04: And then to your question, um, the third um leg to Novos is our formulations.
• 26:05
  SPEAKER_04: And uh this is our bread and butter.
• 26:07
  SPEAKER_04: Uh, we have Novos Core and Novos Boost.
• 26:10
  SPEAKER_04: Novos Core is what we are most proud of.
• 26:12
  SPEAKER_04: This is a formulation.
• 26:14
  SPEAKER_04: Uh, it's it's made up of 12 different ingredients.
• 26:16
  SPEAKER_04: It's the very first formula to address the 12 hallmarks of aging.
• 26:21
  SPEAKER_04: Um, it was uh created um uh with a team of scientists and MDs.
• 26:26
  SPEAKER_04: Uh we have a scientific advisory board of six members from Harvard Medical School, MIT, and the Salk Institute.
• 26:33
  SPEAKER_04: Some really big names in the scientific community.
• 26:35
  SPEAKER_04: For example, Dr.
• 26:36
  SPEAKER_04: George Church, who invented genome sequencing in the 1980s, um, uh, but all of whom are um researchers in the longevity space.
• 26:45
  SPEAKER_04: And so um together we we formulated this.
• 26:48
  SPEAKER_04: It's a patent pending formulation.
• 26:50
  SPEAKER_04: Um, these 12 ingredients, the the total um uh weight of all of these is is almost seven grams of active ingredients.
• 26:59
  SPEAKER_04: When you think of most supplements, they're giving you like 250 milligrams of something or 500 milligrams, uh, but we're we're giving a very uh significant dose based on what studies have found to be the most effective dosages.
• 27:13
  SPEAKER_04: Um and so uh to getting specifically to your question, we wanted to make sure that all of the ingredients um had impacts on aging.
• 27:25
  SPEAKER_04: And if you go to our website and you uh go to the science section at the top and you click on approach, you'll see the approach we took specifically for the formulation.
• 27:36
  SPEAKER_04: And so I'll I'll mention a few of them.
• 27:38
  SPEAKER_04: There are 10 different uh considerations we made, but one I've already mentioned is they have to have the ability to impact aging hallmarks and ideally multiple at the same time.
• 27:49
  SPEAKER_04: Um, they have to have been able to extend lifespan in various animal models, which would then hint at the uh um the biological pathways as being evolutionarily conserved.
• 28:00
  SPEAKER_04: So, in other words, evolution found this to be important enough to make sure that it exists in worms and in mice and in primates and in humans, and therefore, it is fair to believe that this is also going to extend lifespan in humans.
• 28:15
  SPEAKER_04: Now, I say that because it's difficult to measure, sorry, to track lifespan in humans in a study because it would take tens of millions of dollars, decades to complete, and it's just not very feasible to do lifespan lifespan studies on humans, but we can in animals, and we can understand how the substance is working, and then compare to humans, and then we can also look at humans and see when they take these substances, do they display better health?
• 28:42
  SPEAKER_04: For example, lower incidences of aging-related uh diseases.
• 28:47
  SPEAKER_04: Um is it associated with a reduced risk of mortality in humans?
• 28:53
  SPEAKER_04: So these are I've only gotten up to the first five of the 10, but these are different considerations we've made when we uh put all of the different potential ingredients through a filter to then arrive at a smaller subset from which we then dug really deep into the research to get to an even smaller subset to eventually reach the 12.
• 29:14
  SPEAKER_02: Yeah, I mean, you know, it makes sense uh what you're saying, because at the end of the day, you know, it really is about studying the commonalities, like you said, in the evolutionary status of all organisms that match very closely to human, you know, the human genome.
• 29:28
  SPEAKER_02: And I think that is like kind of the standard in in science, I think overall.
• 29:32
  SPEAKER_02: But my biggest question um still, you know, it it's always this idea of um, you know, how do you really measure the value of age, you know, in terms of not just years, but like, you know, there's also this component of like um a good life, right?
• 29:48
  SPEAKER_02: Like in terms of just being alive versus just being actually healthy and alive.
• 29:53
  SPEAKER_02: So I want to ask you, you know, with the approach you guys are taking, um, are you measuring like what like what exactly are you measuring?
• 30:01
  SPEAKER_02: Are you measuring, for example, like um, you know, you had mentioned the epigenome and then doing that test where you can, you know, analyze just based on that what someone's age span is most likely going to be.
• 30:12
  SPEAKER_02: I mean, are you going again and again and like measuring that like after people start taking the product or like how does the the actual testing and the clinical trials and stuff work around this?
• 30:23
  SPEAKER_04: Sure.
• 30:23
  SPEAKER_04: So when it comes to scientific testing, we we also have on our website in the science section a page called evidence.
• 30:29
  SPEAKER_04: And um in there, uh we go over the very fundamentals from which we formulated, which is uh at this point more than uh 220 scientific studies uh for um attesting to the power of our ingredients.
• 30:43
  SPEAKER_04: Then we did um some some um you know user testing to make sure that that there were no side effects.
• 30:49
  SPEAKER_04: Um and so we had dozens of people testing before we launched as a company, uh, making sure there are no side effects, and then also finding out any short-term benefits that they might experience, which we were happy to find there were numerous, for example, improvements in skin health in the form of um hydration and and firmness, which I'll talk a little bit more about in a moment, uh, in in terms of um uh mood.
• 31:12
  SPEAKER_04: So we found that people um were more calm, and uh um that's probably mediated by a few of the ingredients that if we get into those later, I can I can share.
• 31:23
  SPEAKER_04: Uh, and um improvements in energy and sleep.
• 31:26
  SPEAKER_04: And so so though those were all really good early signs.
• 31:29
  SPEAKER_04: We went on from there to do um a skin test.
• 31:32
  SPEAKER_04: It was a very small um in-house study, but we used this device called an indentometer to measure the firmness of skin.
• 31:39
  SPEAKER_04: And we found that all test subjects had improvements in their skin firmness at a minimum of uh 12%, an average of 22%, and a maximum that was significantly higher than that.
• 31:52
  SPEAKER_04: I don't recall off the top of my head.
• 31:54
  SPEAKER_04: Um then we went on to in vitro um studies.
• 31:58
  SPEAKER_04: So we we used uh human cells, um, in some cases, um uh skin cells, for example, and we we so far have um done studies looking at DNA damage as well as cellular senescence.
• 32:13
  SPEAKER_04: So the very first study we ran, we um we had a control that did not get novos, and then um, of course, we had the experiment with novos, and we um we irradiated the cells and we found that novos was able to reduce DNA uh oxidation by um somewhere in the neighborhood of about um uh 50 percent, 45 or 50 percent.
• 32:37
  SPEAKER_04: Yes, very significant.
• 32:39
  SPEAKER_04: The lab that did this for us had done about$7 million worth of studies prior to Novos core.
• 32:45
  SPEAKER_04: They had warned us and said, we've studied all of your ingredients.
• 32:48
  SPEAKER_04: There's no significant improvements.
• 32:50
  SPEAKER_04: We've also done pharmaceutical drugs, we haven't found anything that really wowed us.
• 32:55
  SPEAKER_04: And then they before even calling us, they called their CEO to tell them, tell him our results because we were the first formulation after seven million dollars worth of studies that they found we had such significant results.
• 33:07
  SPEAKER_04: So that that was a really nice positive outcome that that we found.
• 33:11
  SPEAKER_04: We we then went on to really amazing, yeah.
• 33:16
  SPEAKER_04: Um, and and so well, so on that that same theme of DNA damage, I'll skip ahead to the third study.
• 33:21
  SPEAKER_04: So so there's another one that we haven't published yet because we're doing more studies with them, but there is um a laboratory uh in Italy, um, an academic lab that uh administered chemotherapeutics to um to uh human uh cells, and then with again novos and without novos, and found that with a very aggressive chemo, um practic with in the control where there's no novos, practically all of the DNA has double uh strand breaks.
• 33:53
  SPEAKER_04: Uh and so that that's beyond oxidative damage.
• 33:56
  SPEAKER_04: That is like mutilating the the DNA.
• 33:58
  SPEAKER_04: It's almost like uh comparison.
• 34:00
  SPEAKER_02: That's like UV damage.
• 34:01
  SPEAKER_02: That's straight UV dam, like you know what I mean, like really UV dip.
• 34:06
  SPEAKER_04: Yeah, right, exactly.
• 34:07
  SPEAKER_04: It's like I I think of an analogy with a car, it's like oxidative damage would be like rusting of the of the uh exterior of the car, whereas double strand breaks is like slicing the car down the axle, right?
• 34:17
  SPEAKER_04: It's like a completely different level.
• 34:20
  SPEAKER_04: And so uh for that, we we we I can't speak of specific numbers, but uh what I will say is that we have significantly reduced the amount of double strand and single strand breaks of the DNA um after administration of the novos formulation um to those to those cells.
• 34:37
  SPEAKER_04: Um, a third study we did was looking at cellular senescence, and we compared to the gold standard longevity drug uh that all researchers consider to be the best longevity drug in existence, which is rapamycin.
• 34:50
  SPEAKER_04: It's a prescription drug for immunomodulation, typically prescribed for organ transplants.
• 34:55
  SPEAKER_04: It has actually been found to extend lifespan in every stud every species that has been studied, um, but it's aggressive and not everyone wants to take a um uh a prescription drug, especially because of side effects.
• 35:08
  SPEAKER_04: And so um it was found that we had a senostatic property um on the senescent cells.
• 35:15
  SPEAKER_04: So we stopped the senescent cells from spreading and we actually shrunk the size of them by about 45%, and it was at the same order of magnitude approximately as the prescription gold standard rapamycin.
• 35:27
  SPEAKER_04: Um and then getting to humans and more of an in vivo approach, uh what we found was uh we did a case study uh just for the sake of speed and being able to execute quickly.
• 35:38
  SPEAKER_04: Um, this was a small scale, it was um 11 participants.
• 35:42
  SPEAKER_04: Um, but what we found was with epigenetic testing, um, 73% of the participants had statistically significant improvements in their pace of aging.
• 35:52
  SPEAKER_04: And then of those who did not have improvements, zero of them had accelerated aging, which you would expect would happen if they're um uh just because of uh, you know, life lifestyle stressors, right?
• 36:05
  SPEAKER_04: So you would expect there would be some who had accelerated aging, zero did.
• 36:09
  SPEAKER_04: And the p value of the study, so you know, the probability that this is um not a uh sorry, that it is a coincidence was 0.001.
• 36:19
  SPEAKER_04: So well beyond the 0.05 expectation for statistical significance.
• 36:24
  SPEAKER_04: And now we have clinical trials also underway, but um they're they're at the very beginning.
• 36:28
  SPEAKER_04: So I can't I can't say anything about those yet.
• 36:31
  SPEAKER_02: Wow, I'm really blown away right now, Chris.
• 36:33
  SPEAKER_02: This is really, really great data.
• 36:35
  SPEAKER_02: I mean, that's that's very impressive.
• 36:37
  SPEAKER_02: I mean, I know there's a lot of buzz right now around, for example, like metformin um about anti-aging benefits or whatever, but I'm not a, you know, I'm not fully sold on that.
• 36:47
  SPEAKER_02: You know what I mean?
• 36:48
  SPEAKER_02: So like I really, really value what you guys are doing here because the idea, it again comes back to that question that I had asked you was that, you know, is there like, you know, individual targeting of these 12, you know, hallmarks of aging?
• 37:04
  SPEAKER_02: But that in reality, I mean, you have to have a formula that is combating things in a very like, I guess, yeah, I don't know what the real word would be, but it's like a multi, like multi-faceted approach, right?
• 37:17
  SPEAKER_02: I mean, I always think of the human body and for this for everyone listening that, you know, it's it's a moving, living organism, right, guys.
• 37:23
  SPEAKER_02: So everything's changing constantly.
• 37:25
  SPEAKER_02: So for you to be able to target things like signs of aging or the, you know, the real underlying causes of aging, that's going to change day to day.
• 37:33
  SPEAKER_02: And it's also going to change based on you as a person, you know, especially because you had brought up, for example, the microbiome.
• 37:39
  SPEAKER_02: And just for our listeners, you know, to kind of further elaborate on that, you know, your microbiome, for example, is different based on who you are, just like your epigenome is.
• 37:48
  SPEAKER_02: You know, it's something that we're now in science coming to the realization of this individualized need of treatment plans for people, you know, you this one size fits all is very hard to accomplish, I think.
• 38:01
  SPEAKER_02: But what you guys are doing is really so interesting to me because with everything in science, there's a fundamental baseline that you have to work with.
• 38:10
  SPEAKER_02: And I think by figuring out these hallmarks and then targeting these hallmarks, you're establishing that baseline of what longevity science should really be and where it should start.
• 38:20
  SPEAKER_02: You know, so I'm very excited to see what you build upon, you know, with this data and what you've already discovered.
• 38:26
  SPEAKER_02: And um also hats off to you for working with such talented um professionals on your team, you know, on your medical board.
• 38:33
  SPEAKER_02: That's very impressive that you're working with these people.
• 38:36
  SPEAKER_04: Well, thank you.
• 38:37
  SPEAKER_04: Thank you.
• 38:38
  SPEAKER_04: It's um it's as I mentioned before, it is my passion, and and I'm creating products that I myself um want uh to take uh and I want to give to my my my friends, my family, my loved ones, and then of course the community at large.
• 38:52
  SPEAKER_02: So um it makes sense.
• 38:56
  SPEAKER_02: It makes sense, and you know, one thing I love that what you said was this idea of like overall, like you had spoken something about mood, I think, or um just the overall like uh you know, just mood stabilization.
• 39:07
  SPEAKER_02: I think you had said something about that.
• 39:09
  SPEAKER_02: And I noticed you have lithium in your um ingredient list.
• 39:12
  SPEAKER_02: And I like that you have this low dose of lithium in there because it's actually interesting.
• 39:17
  SPEAKER_02: I was, you know, very long ago, there was this psychiatrist I used to follow.
• 39:21
  SPEAKER_02: And he was doing some very interesting work where he was saying that, you know, half the time the patients, even if they were patients that were just, you know, uh seasonally depressed or, you know, whatever it was, it didn't have to be a like a mood disorder, right?
• 39:35
  SPEAKER_02: It was just anything, anyone who would come to him.
• 39:37
  SPEAKER_02: He was what he was doing was using microdosing of lithium.
• 39:41
  SPEAKER_02: And it was working if in all patients, like it wasn't just like one disease or one disorder or no, it was across the board.
• 39:48
  SPEAKER_02: So he had collected the significant amount of data around that one ingredient and its benefits if you use it in the right doses, you know, and so that's really where my next question is, you know, aside from just lithium, is this dosing uh concept and how that was for you and your team to like really nail down the ideal um, you know, amounts of each of these ingredients.
• 40:09
  SPEAKER_02: And, you know, what was that process like?
• 40:11
  SPEAKER_02: And where did you really figure out this metric of, you know, what the right dose is for each ingredient?
• 40:17
  SPEAKER_04: Yeah, so so a quick comment on lithium, which is that you know, the dosage that we use is a microdose.
• 40:23
  SPEAKER_04: So it's a uh, you know, one one hundredth of what you might get in a bipolar setting, for example.
• 40:28
  SPEAKER_04: And it's important for people to realize that lithium is a natural element that's typically found in our food supply throughout evolution, right?
• 40:36
  SPEAKER_04: So yes, um, it leaches through the through the rocks into the water and then into the water supply for the plants, for the animals, and for you.
• 40:44
  SPEAKER_04: Um, and we with water purification and with processed uh foods and factory farming and so on, we don't have lithium in our diet like we used to.
• 40:54
  SPEAKER_04: But um the reason we included lithium was because it has favorable impacts on the epigenome, on lifespan and different animal um uh studies, as well as on cognitive uh disorders like or neurological disorders like uh Alzheimer's and dementia.
• 41:10
  SPEAKER_04: There's a really interesting article published in the New York Times a while back where they looked at different um communities that had lithium in their natural food and water supply.
• 41:23
  SPEAKER_04: And what they found was that there were lower rates of depression, suicide, um, uh rape, murder, all of the rates of all of these went down significantly when it was these microdoses in people's food and water supply.
• 41:38
  SPEAKER_04: So um, so there's all of these longevity benefits, and then it's a nice to have that it also just helps you feel more in control of your life in a sense.
• 41:47
  SPEAKER_04: Um, and so um so that that's a nice to have added short-term benefit um or or midterm benefit that that you get from from the ingredient.
• 41:56
  SPEAKER_04: Now, to your question about dosing for all of these ingredients, uh we went through all of this the scientific papers, and uh, of course, a lot of them are animal studies, and then you you can do um uh you know the the the dose equivalents or the scaling for uh for for humans.
• 42:15
  SPEAKER_04: But then of course there are human studies for all of these ingredients too.
• 42:18
  SPEAKER_04: So everything we use is a natural ingredient.
• 42:20
  SPEAKER_04: It's either found in human biology but declines with time.
• 42:24
  SPEAKER_04: For example, calcium alpha ketoglutarate, um, the alpha-ketoglutarate molecule um is is something that we have um that um uh declines precipitously as we age.
• 42:36
  SPEAKER_04: Um, hyaluronic acid, another one that is in our biology, but we we have less of it.
• 42:41
  SPEAKER_04: But and then there are other things that we have in our food.
• 42:44
  SPEAKER_04: Um it's just found in nature and we've been consuming.
• 42:48
  SPEAKER_04: And so when we looked at the scientific studies, of course, we look at we consider toxicology and uh LD50s, and and then we make sure that we are nowhere near any of those types of dosages.
• 43:00
  SPEAKER_04: Uh, we look at the uh um where side effects might occur in different studies uh for different dosages, and then we also look at like the minimum effective doses and and which dosages are um exhibiting the favorable characteristics when it comes to longevity.
• 43:18
  SPEAKER_04: Um and then, of course, we then have to have this holistic vision, looking at all of the ingredients and uh and and and keeping in mind that we don't want to overdo anything.
• 43:29
  SPEAKER_04: For example, uh if if a if a molecule is a hormetic stressor, right?
• 43:34
  SPEAKER_04: So this idea of hormesis, which is putting a little bit of stress on the body, um, and then the body comes back stronger and more resilient.
• 43:42
  SPEAKER_04: Uh, you can think of that in a macro sense.
• 43:44
  SPEAKER_04: Uh, when you exercise, your muscles will get bigger from the stress you put on them.
• 43:49
  SPEAKER_04: Um, it happens at the microscopic level, too.
• 43:52
  SPEAKER_04: And there are certain like um uh ingredients, uh phytonutrients found in plants, like, for example, terastilbean, which is in Nova.
• 44:00
  SPEAKER_04: Which has a little bit of a hormetic effect.
• 44:03
  SPEAKER_04: So we wanted to be mindful of the hormetic effect and make sure that we didn't overdo the hormesis.
• 44:11
  SPEAKER_04: Same thing with physetin.
• 44:12
  SPEAKER_04: Physetin at higher doses can have senolytic effects.
• 44:18
  SPEAKER_04: But because this is daily administration and because if you go too aggressive with senolytics, you can actually damage nearby healthy cells, including stem cells.
• 44:28
  SPEAKER_04: We didn't want to risk that.
• 44:30
  SPEAKER_04: So we kept the dosage lower.
• 44:32
  SPEAKER_04: So this is I can't give you like a very simple answer, but what I would basically say is that we we looked at the ranges of the dosages, we looked at the the um side effect profiles and toxicology data.
• 44:43
  SPEAKER_04: We looked at the minimum effective dosages, we looked at all of the ingredients and the mechanisms through which they worked, and then we determined an ingredient, sorry, a dosage uh with all of the ingredients in mind that would be um ideal in our you know professional estimation along with the scientists that that were uh part of the project.
• 45:05
  SPEAKER_02: Very interesting.
• 45:06
  SPEAKER_02: Yeah, it's very interesting because I I know that you know that is like for dosing, it makes sense.
• 45:10
  SPEAKER_02: I mean, if you have uh, you know, animal models, yeah, you can superimpose that and do the calculations and stuff.
• 45:17
  SPEAKER_02: But I mean, there is still this thing of really, you know, modulating dose for human beings that is, you know, it's a whole area of science in terms of like you have to be very careful because even though it it makes sense to have a certain dose, um, given what that, you know, if you are testing in a mouse and then you want to transpose that onto a human, you still have to be careful because we will react differently, you know, and depending on just your overall biology.
• 45:43
  SPEAKER_02: But that's a really interesting approach.
• 45:45
  SPEAKER_02: And I and I think it's a great start, you know, in terms of figuring that out because I always ask brands, you know, I have so many brands that come on that are, you know, quote, clinical grade or medical grade.
• 45:56
  SPEAKER_02: And my first question is always, well, what's your dosing?
• 45:59
  SPEAKER_02: You know, where is this concept?
• 46:00
  SPEAKER_02: Because nobody's really, um, I think discussing that.
• 46:03
  SPEAKER_02: And I the reason I bring that up is we had previously spoken about microdosing, and that's just a testament to what I where I'm getting at is that, you know, sometimes you don't need too much of things.
• 46:14
  SPEAKER_02: Sometimes you don't need what you think you'll need for something, you know, a drug or a pharmaceutical or any kind of molecule to work and provide benefits.
• 46:22
  SPEAKER_02: So, you know, I think it's a very um intricate dance in the in the realm of science, you know, figuring this out.
• 46:28
  SPEAKER_02: So I'm very interested to see, you know, how your formula evolves over time.
• 46:32
  SPEAKER_02: I'm also curious to see, you know, if in the future the clinical trials that you guys are going to be getting data back for, like how that turns out.
• 46:39
  SPEAKER_02: But um very fascinating.
• 46:41
  SPEAKER_02: Absolutely.
• 46:41
  SPEAKER_04: Yeah, so yeah.
• 46:42
  SPEAKER_04: So so you know, a couple of a couple of things to mention.
• 46:45
  SPEAKER_04: So, you know, trying to extrapolate from an animal species is the whole like allometric scaling approach, right?
• 46:51
  SPEAKER_04: And uh but allometry is is you can only go so far with that.
• 46:56
  SPEAKER_04: Like you said, like we we might still react differently.
• 46:59
  SPEAKER_04: Um, and it's uh it's not a precise um way to go about doing things.
• 47:04
  SPEAKER_04: So um that's where looking at studies and historical data and and particularly in humans really really comes into play.
• 47:12
  SPEAKER_04: Uh the other thing I'd mentioned is the the whole you know dose response curve concept, uh, you know, this U-shaped uh dosage response curve that that most drugs tend to follow, which is um, you know, essentially like the optimal dose isn't the highest nor the lowest.
• 47:29
  SPEAKER_04: Um it's somewhere in between.
• 47:31
  SPEAKER_04: And you have to really find like where where that that middle ground is to be able to have that that maximal um efficacy um and also then minimizing minimizing any chances for for side effects.
• 47:45
  SPEAKER_04: So yeah, these are things that that we're very mindful of in in all of the products that we we put out, um, as well as any advice or guidance that we give on on our contents um when it comes to other types of supplements that we recommend people consider taking for general health um supplements that we don't sell, but that we're just trying to give some guidance on.
• 48:06
  SPEAKER_04: We we consider those factors.
• 48:08
  SPEAKER_02: Yeah, absolutely.
• 48:09
  SPEAKER_02: And just to add to your point, you know, I know you guys are doing it right, but you know, just for our audience, you know, there is this thing called pharmacokinetics.
• 48:16
  SPEAKER_02: And really what you learn from that, like studying pharmacokinetics with different types of pharmaceuticals is this idea of accumulation over time.
• 48:23
  SPEAKER_02: And I know Chris, you had mentioned the toxicology um, you know, aspect of things earlier on, but I think that's something that uh consumers have to be aware of with like just any supplements.
• 48:33
  SPEAKER_02: You know, I think if you're just out there going to like a GNC or a Walgreens or something, like I just really um urge all of you to keep in mind that, you know, molecules and drugs and any kind of um any vitamin, anything it is you put in your body, it will accumulate over time, whether that's on a cellular level level or subcellular cellular level, I can't speak, sorry, um, it will accumulate.
• 48:56
  SPEAKER_02: And there's that's where toxicology is very important to really keep in mind and to understand.
• 49:01
  SPEAKER_02: Because what I'm seeing a lot of right now in the consumer space is that people are buying all these supplements and they're just basically without knowing it, ODing on them on a molecular level because your body is just getting exposed to too much, you know?
• 49:14
  SPEAKER_02: So that's where I think novos for me, it's very, very exciting, Chris, because you guys are really, you know, you're giving this solution-oriented approach to the average consumer versus them just going into a store and trying to pick out like what supplements are gonna help me, you know what I mean, in terms of whether that's aging well, whether that's energy levels, whether that's, you know, uh whatever it is that you think that you're lacking in, right?
• 49:38
  SPEAKER_02: I mean, you have to go to a reliable source.
• 49:41
  SPEAKER_02: And I think Novos is definitely, definitely paving that that road, you know, in terms of um also supplement science, because, you know, it's really anarchy in that realm, you know, right now, as far as I see it and from a science perspective, you know, there's really no regulation and there's no way of really telling if these supplements are even working.
• 49:59
  SPEAKER_02: And, you know, a classic example I love to state is vitamin D.
• 50:03
  SPEAKER_02: You know, how many people do you guys know out there that or your family member or somebody that is lacking in vitamin D levels?
• 50:10
  SPEAKER_02: I mean, it's like a problem that's getting worse and worse, you know, as we see in medical science yearly, it's getting worse.
• 50:16
  SPEAKER_02: More people are reporting lower uh levels of vitamin D.
• 50:20
  SPEAKER_02: And unfortunately, the what we do, you know, from the medical standpoint is we'll give you, say, for example, 50,000 international units, you know, and say that here you go, take this once a week, and we're just gonna hope and pray it works.
• 50:32
  SPEAKER_02: But unfortunately, what we're noticing with these vitamins and these things that we're providing to help your body is that you're not absorbing them.
• 50:41
  SPEAKER_02: So, you know, that's where I get very fascinated, Chris, with novos, because you had mentioned this idea of nutrition absorption, right?
• 50:49
  SPEAKER_02: Like actual utilization of new nutrients.
• 50:51
  SPEAKER_02: And so I'm very curious, you know, if you could really talk about that aspect, because I think it's very important to educate our consumers about um what nutrient absorption or utilization really means from a science perspective and how you guys are approaching it.
• 51:06
  SPEAKER_04: Sure, sure.
• 51:07
  SPEAKER_04: So um, and there there's one thing that that you you brought to mind uh that that I'd like to comment on, which is uh when when I was starting Novos, um I was going to biotech conferences and uh hearing you know all of the research that was being done in longevity and uh came to realize that everything that was being done was either purely academic or it was biotech pharmaceutical.
• 51:32
  SPEAKER_04: And there was really nothing happening on the consumer side.
• 51:35
  SPEAKER_04: But then when I looked at the supplement space to your point, I felt like the the supplement space was was not very accountable and responsible and um largely as a result of not as much FDA regulation, which is a blessing in some ways and a curse in others.
• 51:50
  SPEAKER_04: And so what I wanted to do was to create a company that that took the best aspects from each of those those respective industries and merge them together into a uh uh a company that kind of stands in the middle uh between those two um types of uh companies.
• 52:07
  SPEAKER_04: And so we we get the benefit of a supplement company in the sense that our ingredients are natural.
• 52:13
  SPEAKER_04: So we don't need to do the FDA um uh you know uh approval um process of testing out um you know rigorously with with tens of millions or sometimes hundreds of millions of dollars before bringing uh the product to market.
• 52:28
  SPEAKER_04: Um and that that means that we could also iterate more quickly, we could launch more products, um, and we could also address you know uh aging as a quote unquote disease rather than having to create something for a medical uh condition, which uh the pharmaceutical side has to create something for some sort of medical condition.
• 52:49
  SPEAKER_04: Um and that that in some sense is a is a limitation for them.
• 52:52
  SPEAKER_04: Uh and then the pros of pharma and biotech is that they are uh very methodical about the research, about the scientific experiments, about proving out efficacy and safety data.
• 53:05
  SPEAKER_04: Um, and so we wanted to bring both to the table and then add something in that no one was doing, which is really just being very transparent with the consumer and making that educating them and making them aware that we are very confident in what we're doing.
• 53:19
  SPEAKER_04: Uh, we don't think we're we're perfect and we will learn along the way, but um we we uh we want the community, the consumer to learn along with us and to be healthier in a in the process.
• 53:30
  SPEAKER_04: Um so so with all of that said to your question, uh when when it comes to uh the absorption of the different nutrients, you know, a couple of quick things that come to mind is of course uh related to the um the solubility of the molecules, right?
• 53:45
  SPEAKER_04: So the fat-soluble molecules like vitamin D or K or A E, um, these these tend to accumulate more in the body, more so than the water-soluble uh molecules.
• 53:57
  SPEAKER_04: Uh water-soluble molecules, you you know, you oftentimes hear you pee it out, though it's not that simple.
• 54:02
  SPEAKER_04: Some some water-soluble soluble uh molecules you might accumulate more so um than than you might think.
• 54:09
  SPEAKER_04: Um, but it is easier for the body to rid itself of of you know a quote unquote overdose of of something like you know, vitamin B12 or the B vitamins in general.
• 54:19
  SPEAKER_04: Um so uh yeah, so when it comes to that, and especially when it's uh general health supplements, as we put it, as opposed to longevity health supplements, um we we suggest that people exercise more caution when it comes to these fat-soluble um vitamins.
• 54:37
  SPEAKER_04: Like, for example, you mentioned vitamin D.
• 54:39
  SPEAKER_04: So that's something you probably want to get tested once a year or or twice a year, just to make sure that your your levels are within a healthy range and you're not going too high or getting too low.
• 54:50
  SPEAKER_04: Uh, and and that can then apply also for um uh you know vitamin A and vitamin E and so on.
• 54:57
  SPEAKER_04: Uh, and then for for the water soluble vitamins, you you can uh be a little bit more liberal with with your uh intake of them.
• 55:04
  SPEAKER_04: Of course, you don't want to go to you know real extremes.
• 55:09
  SPEAKER_04: Um, but uh, you know, if if you have a if you have a uh a B complex vitamin or something and you see that you have like 1,000% of the daily value of vitamin B12, like that, that's fine.
• 55:20
  SPEAKER_04: Um and it's fine because of what I mentioned, because it's water soluble, but also because the RDAs that the government has established are um many would believe are are too low for for most of the um essential nutrients out there, largely because the the way that they do their studies is to um to just prevent any sort of um uh you know uh condition, um illness from taking form, like you know, scurvy, for example.
• 55:47
  SPEAKER_04: Um but but not for the sake of optimized health.
• 55:51
  SPEAKER_04: And the second thing is that they're not really long-term studies, it's just like looking for making sure that these things, these illnesses don't take place, but not about like over the course of years or decades, like what is the ideal level for you to have.
• 56:04
  SPEAKER_04: And so generally speaking, most of the nutrients, not all, but most of them are um a little bit, the RDAs are are a little bit on on the more conservative lower end.
• 56:14
  SPEAKER_04: And we as a company suggest that you you might want to go a little bit higher on on some of those nutrients.
• 56:19
  SPEAKER_04: Then of course, it's individual.
• 56:21
  SPEAKER_04: Um, so like I, for example, I have a genetic polymorphism uh called MTHFRC677T.
• 56:28
  SPEAKER_04: I'm homozygous for it, and so that means that I don't methylate as well.
• 56:32
  SPEAKER_04: And so um, you know, a good 15% approximately of the population is also homozygous for this, and uh maybe another 30% are heterozygous for it.
• 56:42
  SPEAKER_04: So it's pretty common, but it means that I need more uh B vitamins and and more methyl donors uh than the average person does.
• 56:49
  SPEAKER_04: And so I I take, you know, my my multi or my B my B complex every day, and I I get some methyl donors in the form of whether it be choline from egg yolks or um you know, you can also supplement with uh choline or phosphatidylcholine or or trimethyl glycine, you know, all of these different types of uh supplements to be able to increase your methyl uh donors a little bit.
• 57:12
  SPEAKER_04: So there are individualistic um aspects to it that if you really wanted to dig into, you could.
• 57:19
  SPEAKER_04: Uh, but there are some general rules just when it comes to like fat-soluble versus water soluble, and um, which ones you can be a little bit more liberal with and versus which ones you want to be a little more conservative with.
• 57:31
  SPEAKER_02: Absolutely, absolutely.
• 57:32
  SPEAKER_02: No, I make sense what you're saying, and I I I fully understand that, you know, you want to take fat-soluble vitamins with fats, right?
• 57:38
  SPEAKER_02: I get I get that, but I also I think for me it was more of a question of, you know, just gut permeability and you know how we are dealing with now with like more leaky gut syndromes everywhere, you know, or what people are saying to be leaky gut, you know.
• 57:52
  SPEAKER_02: Um, and I I my big the big reason why I asked was because I think overall, you know, we're seeing this reduced absorption of what we really need to for just optimal health because of things like too much preservatives in our food, because of things like that are just training our body to not function as it would if you grew up, for example, in the woods somewhere, right?
• 58:14
  SPEAKER_02: Like, I mean, I have grandparents who lived in rural India and they both, you know, both my grandfather and my grandmother, like maternal side, lived to be over a hundred years old.
• 58:23
  SPEAKER_02: And all they ate was uh farm agriculture land, you know, uh grown by themselves, like the food they grew for themselves, you know, and it was not riddled with all the all the crap that we deal with now in the Western world.
• 58:36
  SPEAKER_02: And they lived to be very, very healthy, you know, and not they weren't just a hundred some years old, they were healthy at that age.
• 58:43
  SPEAKER_02: And I can't, you know, help but wonder, you know, what is it that we're doing in Western society that's leading to this, um, you know, just I guess uh, you know, speeding up the process of this aging, but also even if we do live to be longer, like live longer, like we're not living, you know, better lives, is my point, right?
• 59:03
  SPEAKER_02: And that's where I think the absorption part really was very interesting to me because one of the things that I've noticed with a lot of patients with various disorders is that it really comes down to are you absorbing the normal nutrients your body needs?
• 59:16
  SPEAKER_02: Because if you go to your doctor and get a blood blood work done, you know, and and really test and see if you have the right amounts, you guys will be shocked sometimes, you know, what you're lacking in.
• 59:27
  SPEAKER_02: So I that's why I'd asked you, Chris.
• 59:28
  SPEAKER_02: But I think your answer was wonderful.
• 59:30
  SPEAKER_02: So thank you so much for sharing that with us.
• 59:32
  SPEAKER_02: Um, I think just to round out the interview, I want to ask you, what is the future for Novos?
• 59:36
  SPEAKER_02: Like, what are you guys looking to do, you know, in the coming years?
• 59:39
  SPEAKER_02: Um, I know you had mentioned clinical trials, very exciting, but like just, you know, an overview, if you could provide us.
• 59:46
  SPEAKER_04: Sure.
• 59:47
  SPEAKER_04: Yeah.
• 59:47
  SPEAKER_04: So so we we as a company intend to always be on the you know tip of the spear when it comes to longevity research.
• 59:54
  SPEAKER_04: And uh we do this by being very close with the scientific community, whether it be our scientific advisory board members that you can see on our website, or it's the you know, more than a dozen other scientists that we regularly work with that you you don't see on our website.
• 1:00:09
  SPEAKER_04: Um, and and that we we expect as we grow, we'll also grow into the the the uh relationships that we have with with scientists as well as medical doctors who are practicing uh you know uh longevity medicine in their clinics.
• 1:00:24
  SPEAKER_04: Uh and so uh you know along those lines, that means that as scientific discoveries are made and scientific innovations are are made, uh we we intend to bring them to novos and then to you, the consumer.
• 1:00:38
  SPEAKER_04: So that will mean uh future formulations, it will mean future tests um and and uh you know experiences for you to be able to um adhere to a long more uh a lifestyle that's more conducive to longevity.
• 1:00:53
  SPEAKER_04: Uh it will mean additional content and expanding that beyond what we currently have.
• 1:00:59
  SPEAKER_04: Um and so we envision ourselves as being, and and I believe we we already are this, but there's just not as much public awareness for longevity as as would be ideal, uh, as a longevity platform.
• 1:01:11
  SPEAKER_04: And as consumers become more aware of the idea of longevity, we hope that they choose us as being that platform for transparent, honest information, um for the best solutions that are available.
• 1:01:25
  SPEAKER_04: Um that's that's what we always want to do is is provide the best solutions that that um that you can possibly um possibly find out there on the market.
• 1:01:34
  SPEAKER_04: And so um we we intend to adhere to that as as we grow and as as the scientific uh body of evidence grows.
• 1:01:42
  SPEAKER_02: I love that.
• 1:01:42
  SPEAKER_02: And you know what?
• 1:01:43
  SPEAKER_02: In my books, you guys are the hallmark for longevity science.
• 1:01:46
  SPEAKER_02: So I really, really applaud you and your work and really where it feels like the the vision you know you've shared with us is just so touching to me as a human being that you've come from this very genuine place with what you're doing.
• 1:01:58
  SPEAKER_02: And I am just so excited to see that this is happening and that you're doing this and you're bringing this to the world because we need more people like yourself and your team that are really dedicated to understanding human health and understanding how to create accessible options like Novos is doing.
• 1:02:15
  SPEAKER_02: I really encourage everyone that's tuned in for this episode.
• 1:02:18
  SPEAKER_02: You guys have to check out this brand.
• 1:02:21
  SPEAKER_02: I'm not joking.
• 1:02:22
  SPEAKER_02: If there's one brand when it comes to anything ingestable and in general, I mean, in general, when it comes to longevity, it's this.
• 1:02:29
  SPEAKER_02: You know, I, like I said, have been very, very excited to interview Chris, you know, ever since I learned of the brand.
• 1:02:34
  SPEAKER_02: And I am very excited, you know, even now, even more excited now that I've spoken to him about just the the overall vision, because this is the next frontier, in my opinion.
• 1:02:44
  SPEAKER_02: You know, you we have to support companies that are doing this kind of work and doing it with such good diligence and due diligence.
• 1:02:51
  SPEAKER_02: So I really encourage everyone listening, check out novoslabs.com.
• 1:02:55
  SPEAKER_02: You're gonna find all this information that Chris has mentioned on there.
• 1:02:58
  SPEAKER_02: And I really, really encourage you guys to do that homework and to dive in, you know, dive into this and take your health in your own hands in some ways where you're learning and you're becoming more knowledgeable and then ask questions, you know, wherever you know, find holes or questions for yourself, ask them and we'll definitely pass them along to Chris's team.
• 1:03:15
  SPEAKER_02: But Chris, thank you so much.
• 1:03:16
  SPEAKER_02: This has been such an honor, and I would absolutely love to host you again anytime if you have time in your schedule.
• 1:03:22
  SPEAKER_04: Oh, thanks so much, Ecto.
• 1:03:24
  SPEAKER_04: It's it's been a pleasure.
• 1:03:25
  SPEAKER_04: And I will say that your your questions are are among the more sophisticated questions that I've been asked on podcasts, so I really appreciate that.
• 1:03:32
  SPEAKER_02: Thank you so much.
• 1:03:33
  SPEAKER_02: And for everyone listening, I will be back next time.
• 1:03:36
  SPEAKER_02: Hey guys, so I hope you love that episode.
• 1:03:39
  SPEAKER_02: Please make sure to hit subscribe if you're tuning in to us on any podcast platform.
• 1:03:44
  SPEAKER_02: We are available on so many different platforms.
• 1:03:46
  SPEAKER_02: So wherever it is that you're tuning in, just go hit subscribe.
• 1:03:49
  SPEAKER_02: You will be immediately notified when we publish new episodes.
• 1:03:52
  SPEAKER_02: This way, you're able to tune in to amazing insights from experts, brand founders, industry leaders, authors, all the wonderful people that we host.
• 1:04:01
  SPEAKER_02: And that's very important for me because I love to hear from you guys and really understand what you love and what you want to hear more of.
• 1:04:08
  SPEAKER_02: Also, make sure to give us a follow on all of our social media outlets.
• 1:04:11
  SPEAKER_02: We're available on Instagram, TikTok, X, you name it, we're there.
• 1:04:16
  SPEAKER_02: We also have a blog on Medium.
• 1:04:18
  SPEAKER_02: So if you're a reader and you love Medium blogs, check us out on Medium.
• 1:04:22
  SPEAKER_02: We publish some really great articles on there that do deeper dives than just what's available on the podcast.
• 1:04:27
  SPEAKER_02: And it's really a great place for all of you science geeks out there that want to learn a little bit more.
• 1:04:32
  SPEAKER_02: We go above and beyond with our research and making sure we're bringing you information that you usually probably won't hear about in other outlets.
• 1:04:38
  SPEAKER_02: So check us out, leave us a comment, leave us a review, and we'll be back next time with another episode.
• 1:04:43
  SPEAKER_02: Thank you.