Latest / The Dr. Randi Show / Why Platelet-Derived Exosomes Are Becoming the Gold Standard in Aesthetics – Alisa Lask
Transcript
- 0:03The views expressed in this podcast are for informational
- 0:06purposes only and do not constitute medical advice.
- 0:10This episode of the Doctor Randy Show is proudly sponsored by New
- 0:14Beauty, the ultimate authority in beauty and aesthetics.
- 0:17Whether you're looking for the latest innovations, expert
- 0:20insights or trusted recommendations, New Beauty is
- 0:24your go to source. Visit newbeauty.com to stay
- 0:27ahead of the trends and discover what's next in beauty.
- 0:30Now let's get into the episode. Hello.
- 0:33Everyone and welcome to the Doctor Randy Show, where
- 0:36innovation meets aesthetics and the industry gets real.
- 0:40Today we have a special guest who has LED some of the most
- 0:43iconic brands in aesthetics. She's also taken science from
- 0:47the Mayo Clinic and turned it into one of the most talked
- 0:50about skin care lines in the country.
- 0:52She's also redefining what innovation looks like in the
- 0:55world of regenerative beauty. Please welcome Alyssa Lask, CEO
- 1:00of Rion Aesthetics and the force behind Plated.
- 1:03Welcome, Alyssa. Thank you so much for having me.
- 1:07Of course, we're so glad to have you here today and I've had a
- 1:10chance to try the products. So excited to dive right in and
- 1:13talk about it. Alyssa, you, after doing a bunch
- 1:16of research for the podcast, so much of an exciting career
- 1:19you've had. You've LED a rich career in
- 1:23aesthetics, medical device, pharma, all different industries
- 1:27before going to Rion. So that's exciting.
- 1:30What really shaped your decision to focus specifically on
- 1:34regenerative aesthetics? Yeah, that's a wonderful
- 1:37question. And I think when I was
- 1:40originally talking about this, I really didn't want to get
- 1:42involved. I was like, oh, there's so much
- 1:44charlatans and craziness going on in this exism industry
- 1:47because the time it was really like half baked.
- 1:50And what happened was I was convinced by a dermatologist
- 1:53just north of you in West Palm Beach to go out and meet these
- 1:56incredible physician scientists. So interventional cardiologists,
- 2:00they've been working on regenerative medicine for 20
- 2:03plus years at the Mayo Clinic in Rochester, MN.
- 2:06And when I went up to meet them, I was just in awe with the
- 2:09science, the technology, and I just knew that we could build a
- 2:13legacy in aesthetics. The story that it coming from
- 2:17the Mayo Clinic is phenomenal. This is not just marketing, this
- 2:20is science, right? It is absolutely where biology
- 2:24biotech meets beauty because this was in the labs at Mayo
- 2:29Clinic for, you know, 15 plus years before it ever saw to the
- 2:32light of the day. But really, the science was too
- 2:34good to not bring it into skin care.
- 2:37So at what moment did you realize, hey, this field of
- 2:41exosomes, platelet derived therapy would really start to
- 2:45play a significant role in aesthetics and you wanted to be
- 2:48a part of it? My whole career has really been
- 2:50based on science, and I really believe in brands that have good
- 2:53science behind them. And I think the thing that
- 2:56always worried me about the skin care industry was it was there's
- 2:59no proof. It was just promise, right?
- 3:02And so I wanted to bring proof instead of promise to skin care.
- 3:05And what I liked about this particular technology is there
- 3:08was $150 million in research years and years studying this.
- 3:13And then it was also kind of later on being developed for
- 3:16other things beyond just skin care.
- 3:19So I thought really we can do something different instead of
- 3:21just talking about science, really bringing true biotech to
- 3:25this industry. From the plated line, clearly
- 3:28you made the right decision. And I think what we realize
- 3:31people keep saying exosomes, these technologies are the
- 3:35future, but it's actually not the now, right?
- 3:38I mean, this is what's happening in the industry now.
- 3:40So let me ask you this. What do you think has been the
- 3:43hardest part about helping people understand what exosomes
- 3:48actually do and getting both clinics and patients to really
- 3:53trust the new science versus what we've all been trained on
- 3:56for skin care for so many years? Yeah.
- 3:58Well, biology was a long time ago for all of us, right?
- 4:01And I think we've been so focused, especially on
- 4:02aesthetics, on injectables and lasers and all these things that
- 4:04we haven't really talked about anything like this.
- 4:07And I think the problem was there's a lot of people that are
- 4:10just embracing that term, but not actually really delivering,
- 4:13like I said, the science behind it.
- 4:15So in our bodies, just simply, exosomes are like the cell to
- 4:18cell communication. You have thousands of exosomes,
- 4:21right? You don't want the one that
- 4:23signals, you know, cancer or inflammation, right?
- 4:26There's certain ones that signal cell and skin renewal.
- 4:30And those are the ones that we're getting from platelets.
- 4:34I think for the listeners now, we've talked about the science a
- 4:37little and Mayo Clinic, which is a name that people know in their
- 4:40home even though maybe they've never been there or experienced
- 4:43it. So came out of Mayo Clinic
- 4:45Science. How did it go from medical
- 4:48breakthrough to beauty brand? The scientists that we're
- 4:50working on this for cardiac application, so this came from
- 4:53the Van Cleave Cardiac Regenerative Medicine Center.
- 4:56Oftentimes they wear gloves in the lab.
- 4:58And what happens when you wear gloves a lot?
- 5:00Anyone that's in the medical industry, sometimes your hands
- 5:02get really dry and red and irritated.
- 5:04And what they were noticing when they were putting this human
- 5:07platelet extract or our now renewism technology on their
- 5:10hands was they were noticing like a remarked difference in
- 5:13how their skin looked. And so the founder and his wife,
- 5:16Emily really started thinking, gosh, this could be more than
- 5:20just this cardiac application. We could do something in the
- 5:23beauty industry. And I came along to kind of
- 5:25consult on the medical side and realize we had something so
- 5:28special. This shouldn't go to Sephora.
- 5:30This shouldn't go right now to Walmart, right?
- 5:31This is a true professional grade biotech meets beauty
- 5:36advancement. So we could really create
- 5:39something that's totally different in this space.
- 5:42Absolutely. And I think that the whole
- 5:44regenerative aesthetics business may be a new term to the people
- 5:51outside of our industry, right? Like we know internally what
- 5:55that means, but for our listeners and viewers that are
- 5:58hearing that for the first time, how can we explain what that
- 6:02means? I think quite simply, science
- 6:04has caught up to the fact that we no longer have to rely on
- 6:07chemicals or plant ingredients. We can use the power of the
- 6:10human body, which we know has an incredible power to heal, power
- 6:14to do things. And we can use that in our skin
- 6:16care to help renew, help the appearance of wrinkles and all
- 6:19the things that we want in our anti aging skin care.
- 6:22I think it's phenomenal. So what exactly is Renewazome
- 6:25and how does that set the plated products apart from other
- 6:30exosome brands that we're seeing pop up everywhere?
- 6:33So no other brand can have platelet derived exosomes.
- 6:36We have a patent on that. So it's a proprietary method
- 6:39that we procure these and that we ensure that they're shelves
- 6:43stable within the formulation. And so Renewazome is our unique
- 6:47exosome technology in a skin care.
- 6:50So you have your own methodology for creating your own ex's homes
- 6:54and that's what's working. And clearly it's working because
- 6:57I think I read that you're in over 4000 clinics.
- 7:01Is that correct? Yeah, so and we last year in
- 7:032024, we got the time best innovation of the year.
- 7:07We're the only skin care recognized last year, and I
- 7:09think we've gotten, you know, awards across all kinds of
- 7:12beauty channels, new beauty as well as many.
- 7:16Others does awards really affect business for you, like receiving
- 7:20a new beauty award, obviously it's a great accomplishment, but
- 7:23how do you think that affects customers and purchasing and
- 7:26just everything overall, even credentialing the business?
- 7:30I think it's all about credibility.
- 7:31I mean, you and I would go on our Instagram and there's so
- 7:34much noise, right? And how do you cypher through
- 7:36all these, like charlatans and these people making these
- 7:40absolutely exotic claims that things can solve everything for
- 7:43you? And I think that gives some
- 7:44credibility. So when you see that sticker,
- 7:46that seal from some of these places like New Beauty, I think
- 7:49it's really, really important for the brands.
- 7:50That means that the team at New Beauty has taken the time to
- 7:53look at these and really make sure that what they're promising
- 7:56is really what they're delivering.
- 7:57Absolutely. And there is a lot that goes
- 7:59behind that. I know at least at New Beauty,
- 8:01there's a lot of testing and a lot of research that goes into
- 8:04picking those New Beauty award winners.
- 8:07So Congrats on that and on that topic.
- 8:11Not all exosomes are created equally and that is such a hot
- 8:15topic right now. Every time we do a show that
- 8:18seems to come up. Why did Rion choose platelet
- 8:22derived exosomes, and what makes that different from the ones
- 8:26maybe we're seeing coming from plant or stem cell sources?
- 8:30Yeah. So what's different about
- 8:31platelets is if you think about it, when you slice your finger,
- 8:34what's the first responder to that wound, the sight of need,
- 8:37it's your platelets, right. So they have a unique ability to
- 8:41renew the skin. And what's neat about this
- 8:43source is it's a cellular, many other sources with exosomes,
- 8:46adipose tissue, MSCS, these are not a cellular platelets have no
- 8:50cell nucleus. There's no reason to worry about
- 8:53DNA or any of the things that you have to be concerned about
- 8:55when you start thinking about human derived ingredients,
- 8:58right? This is a very sophisticated
- 9:00process and there is nothing with pure exosomes intact.
- 9:05That's probably going to cost 599 in the supermarket or in CVS
- 9:09or Walgreens. And in fact, you know, if you
- 9:12think about it, axosomes are much like if you have chickens
- 9:15or you get farm fresh eggs, you can get those farm fresh eggs
- 9:18and you can leave them on your countertop and they don't need
- 9:21to be refrigerated, right? So axosomes are like that.
- 9:24They have this lipid barrier and they're very well protected.
- 9:27But if you crack them or you put them in an environment with
- 9:29ingredients or pH that they don't like, they're just like an
- 9:32egg that cracks on the counter. It's almost instantly destroyed.
- 9:35So how we keep these axosomes intact and that you they're
- 9:38still able to do their job when they're, and formulation is the
- 9:41magic behind the science. Like you have exosomes on your
- 9:44hand now, but they're not actually going to be able to do
- 9:46anything in a formulation that sits on the shelf.
- 9:48And so the real science and our proprietary, you know,
- 9:52methodology allows us to have those shelf stable exosomes in a
- 9:55formulation that are the right ones.
- 9:57And I think that explains so much because I think there are
- 10:00people confused because there's so much different messaging
- 10:03going out right now. So five years from now, what
- 10:06would you want to read on the headline for Rion aesthetics of
- 10:10how they're making things happen right now?
- 10:12So I think in five years that we really want to see that platelet
- 10:16Dr. vaccine is seen as the gold standard in skin treatments.
- 10:19You know that we've really not just become the fastest growing,
- 10:22but we are the gold standard. We've taken over.
- 10:24I mean, since retinoids, there hasn't been a lot of like really
- 10:26new innovation, right? A lot of little small stuff, but
- 10:28not big stuff like this. So I think we want to look back
- 10:31and say we built a legacy. I think we want to say that we
- 10:34built it on good science and that we're continuing to
- 10:36innovate and doing good studies to support that.
- 10:39And then I hope in five years that we started, we're working
- 10:41on some FDA trials and for the aesthetic industry, that's
- 10:44really exciting. This is a different exosome, we
- 10:45call it our PEP, a purified exosome product, which is
- 10:48different than what's in our cosmetics, but we're working on
- 10:50some injectable treatments for hair loss, for wrinkles, so we
- 10:53can bring true regenerative medicine to aesthetics in these
- 10:57injectable exosome treatments. And again, remember now no
- 11:00exosomes are approved for FDA for injection.
- 11:03So there is nothing out there. It is topical use only.
- 11:06But we are doing the right thing and going through the trials to
- 11:09hopefully get these advances to the industry.
- 11:11And what I have noticed is that the plated line has quickly
- 11:17built a reputation in aesthetics.
- 11:19What do you think is driving all that buzz around it right now,
- 11:22and how did that happen? I think a lot of things happened
- 11:251. I think people were just ready
- 11:27for again, promise and proof and really something new.
- 11:31We were using the same thing. And I think, you know, plant
- 11:33derived is fine, but it's just like eating a carrot.
- 11:35You get nutrition. You're not like elevating
- 11:38yourself to really human derived ingredients.
- 11:40And that's what we're doing here.
- 11:41And I think it just people are ready to accept this now.
- 11:44They understand the science has caused up and that these are
- 11:47safe, very, very effective and kind of the next generation of
- 11:51what's new in skin care. So I'd love to go through the
- 11:54line a little bit. I got the chance to experience
- 11:57it. So Intense becomes the hero of
- 12:01the story, the hero product. Is that correct?
- 12:03Yeah, So Intense was our first product that was created.
- 12:06It has the highest concentration of exosomes.
- 12:09It's for someone like myself that was out in the sun all the
- 12:11time as a child, still in the sun now living in Florida like
- 12:14you, and really needs the most bang for their buck.
- 12:17And that's our absolute best seller.
- 12:19It's very thin. It dries quickly, it layers
- 12:22easily. The key though, and this is
- 12:24important, the key with platelet drives exosomes is they have to
- 12:27go and clean skin. There are a lot of things that
- 12:30our platelet drives exosomes don't like, whether it's
- 12:32ingredients we use in our sun care or cosmetics or even toners
- 12:36or makeup wipes. So clean skin is really
- 12:38important and then you have to wait a few minutes and then you
- 12:40can layer with it whatever you want.
- 12:42Excellent. And we have a little bottle.
- 12:45Packaging is beautiful. Great packaging and it looks
- 12:48very science derived as well. And it's refillable.
- 12:51So if you screw the bottom off, it's we're the first refillable
- 12:53in the professional channel if you just turn the bottom.
- 12:56Didn't even notice. Yeah, it was amazing.
- 12:58So I really wanted to make sure think about how much we have all
- 13:02these bottles that are this big and it really only has this
- 13:04little product in it. They're easy to travel with.
- 13:06They don't take up so much space in my cabinet.
- 13:08You get what you buy. It's not trying to trick you
- 13:10that you're getting something bigger and all this fancy
- 13:12packaging. We literally try to do
- 13:14refillables and and do something different.
- 13:17That's amazing. You know what, you're right
- 13:19because I had a product recently that is one of those where you
- 13:24like kind of mashed down on and then the product pops up and the
- 13:28product stopped coming up after I used it like 3 times.
- 13:31So I had to like pry in there with a knife to get that thing
- 13:33out of there. It was like a tiny little was
- 13:36like half an inch. It was like 3 inches of space
- 13:38just hanging out in there. So very deceiving.
- 13:41You're right, that's very. Common, right?
- 13:42They buy and they put weight in the skin care to make you feel
- 13:44like you're buying more. And I just felt like we, we
- 13:47named the product Plated because I wanted to own the source and I
- 13:49wanted to be authentic with the brand and really not trick
- 13:52people into you're getting more than you think you are.
- 13:54No, this is what you're getting. It's from platelets.
- 13:57We're so proud of our source. We're going to name our product
- 13:59Plated. I love it.
- 14:01So you came up with that name? We did.
- 14:03Yep. And then we have Calm, which is
- 14:07slated to help after treatment. Is that right?
- 14:11Yeah. So what we've learned is it's
- 14:12really important to get, you know, kind of that return to
- 14:15recovery as fast as possible to use the CALM a few times a day
- 14:19after treatment. But even better, you can prime
- 14:21your skin for a week or two, even a few days before you go in
- 14:24and get your treatment. It really Revs up the fibroblast
- 14:27and really improves those post recovery downtime which we all
- 14:30hate. There's nothing worse than
- 14:32trying to go to work the next day or be on a conference call
- 14:35and your face is all red. So you really want to reduce
- 14:37that recovery time and not we have published clinical results
- 14:39that CALM can help do that. And I love how the names really
- 14:43correlate to what they actually do, which is really cool because
- 14:47sometimes it's a little confusing, right?
- 14:49This one is called daily, so we use that daily, so it's very
- 14:53easy to use. And I did notice that there was
- 14:57a hair product in the package that you sent me.
- 15:00So let's talk about that. What made you go from skin to
- 15:05hair? Yeah.
- 15:06So this obviously started as a complete skin program.
- 15:09But as we were starting to explore kind of hair on that,
- 15:12once we talked about the FDA injectable side, we started
- 15:16having a lot of people ask us, well, you know, have you tried
- 15:18this for hair? And I was like, I don't know.
- 15:20I wasn't like a true believer. And I was like, listen, let's do
- 15:23a true clinical study. So just like a pharmaceutical,
- 15:26we set up a double-blind randomized SEBO controlled
- 15:29study. We did it with a internationally
- 15:31recognized plastic surgeon. And when we published it in a
- 15:34peer reviewed journal, like we got such good results,
- 15:37statistically significant good results and incredible before
- 15:40and afters that we were able to get into this publication.
- 15:42So the idea again was we only put the plated name on it when
- 15:47we have good science behind it. We don't just go, oh, we should
- 15:49be in hair and eyebrows and all these things.
- 15:51We wait and we do the work behind it before we launch the
- 15:54product. So, you know, hair is extremely
- 15:57fast growing and I think people are really starting to
- 16:00understand it's just super easy. You just can put it on the
- 16:02morning, you can go out. It's not greasy, it won't impact
- 16:04the coloring on your hair and you need just need one dropper.
- 16:07It's really simple and less is more.
- 16:09Well, I think that the hair conversation is becoming more
- 16:14common and people are talking about it and the fact that as we
- 16:17age, we lose hair. And sometimes it's not even
- 16:19aging. Sometimes it's just, you know,
- 16:21things that happen right in our diets and whatever is going on
- 16:24our life. Sometimes it's just stress.
- 16:26So I think it's great that we have a hair product to turn to
- 16:29now. My question that I'm curious
- 16:32about, it sounds like you're constantly doing a lot of
- 16:34research, but it sounds like the science is changing so rapidly.
- 16:39How do you make sure that you're staying ahead of anything that's
- 16:42new, that's changing in this industry?
- 16:45We are so blessed that there is a Rion Medical Group that is
- 16:49doing what I call very noble cause research and we're
- 16:52learning so much from them. So they have 30 INDSI think with
- 16:55the FDA, which means they're exploring 30 different areas.
- 16:58I think they're on phase two for diabetic foot ulcer.
- 17:01They're doing knee osteoarthritis, heart attack.
- 17:03So all these medical studies and we are able to learn from every
- 17:07single one of them and see what we can apply to the aesthetic
- 17:10industry and what we're doing as well in skin care.
- 17:13So Melissa, there's still a lot of confusion, right, about what
- 17:19are exosomes, How does it work in aesthetics?
- 17:21What would you say? Because I hear things all day
- 17:24long are the biggest misconceptions you hear and how
- 17:28are you working to change those narratives?
- 17:30I think there's a couple. I think the first is plant
- 17:33exosomes. Plant exosomes cannot, at least
- 17:36there's no published data, communicate with human exosomes
- 17:39or cells, right? They just, it can't, there's no
- 17:41published data. So while there may be nutrients
- 17:44like eating a carrot from a plant exosome, it is very
- 17:48different than a platelet derived human sourced exosome.
- 17:53I think that's the biggest thing.
- 17:54I think the second thing is that exosomes, they're all the same.
- 17:58They're not like we talked about, there are all kinds of
- 18:02exosomes in your body and you don't want the wrong one.
- 18:04So the level of sophistication a company needs to make sure
- 18:08you're getting the right ones is extremely high.
- 18:11This is not something you and I are going to do in our backyard,
- 18:13right? This took them years, 15 years,
- 18:16$150 million in research to come up with this.
- 18:19So while everyone's slapping stickers on and saying that they
- 18:23have exosomes, it is extremely difficult to get these shelves
- 18:26stable in the bottle. And then I think the third is
- 18:30just there's a lot of over promises out there.
- 18:32There's been a lot of FTA warning letters.
- 18:34People say axosomes fix autism, they fix this and that all these
- 18:39just extreme over promises. And then that just sets the
- 18:42consumers up to, you know, question everything.
- 18:45And so I think that's why going to your provider, not just
- 18:48buying some skin care online, really making sure there's a
- 18:51science, the proof behind something, not just the promise
- 18:54of the Instagram ad. Absolutely.
- 18:56I couldn't agree more. And I think that you're right.
- 18:58Sometimes the promises get to be so much that you're like, wait,
- 19:02wait, wait that there's no way it can do all those things.
- 19:05So then people start doubting it across the board.
- 19:07But it sounds like you've really dialed in the science very well.
- 19:12So you've already told us what's the best way to use the plated
- 19:16products on clean skin, not even to put a toner on 1st, correct?
- 19:21The exosomes again, human derived ingredients like a
- 19:24certain pH and they don't love have a lot of ingredients.
- 19:26And so I was using Neutrogena makeup wipes with the oil
- 19:29because it was beautiful. Took all my makeup off.
- 19:31It was so easy, but I'm lazy. I wasn't rinsing my face.
- 19:34And you know, our founder was like, you realize oils like
- 19:36destroy the exosomes. So I'm like, oh, so it's really
- 19:39important if you do, you know, use the oil or somebody take the
- 19:41makeup off that you just rinse your face, it can be wet and
- 19:44just then put the exosomes on, let them absorb and then you can
- 19:47do whatever your normal routine is.
- 19:49OK, perfect. And then if somebody wants to
- 19:52use the entire line, do you suggest that?
- 19:56So I don't think you need to use the entire line.
- 19:58I think we'll see a lot of people start an intense and then
- 20:01transition to daily. It's a little more cost
- 20:03effective. It's the same cost with double
- 20:05the size and you could use daily twice a day.
- 20:07It's the same as using intense once a day.
- 20:09We also see a younger population that just likes the eye serum.
- 20:12They may not need, you know, a full serum at their age, but
- 20:15they've got these eyes that puffy and tired and so they love
- 20:18the eye serum. And then I think the hair is for
- 20:20someone that has a need. It's not everyone.
- 20:22We see a lot of postmenopausal postpartum women that are losing
- 20:25a. On a hair, and I will say the
- 20:27hair, once you're shiny, it's too late, right?
- 20:29So you got to start early and you got to be patient.
- 20:31Hair takes like 4 to 6 months to make a difference.
- 20:33So don't judge it one month or two months, like give it the
- 20:36full go. Now we understand, and that's
- 20:39great advice, that the daily is like using the intense twice a
- 20:43day, right? So.
- 20:45Use the daily twice a day. It's like using intense once a
- 20:47day, yeah. OK, perfect.
- 20:48And is it better to use it in the morning or at night?
- 20:51I think it really depends on your routine.
- 20:53You know, I like to use it at night.
- 20:54It's the last thing before I go to bed and nothing else that I
- 20:56need. If you like to use a retinoid, I
- 20:58use it at the opposite. So if you use a retinoid at
- 21:00night, I would use the intense in the morning so you're not
- 21:02putting them together. So it really depends.
- 21:04That's the nice thing about this.
- 21:05It's really smart technology, it's really flexible.
- 21:07It's not you have to use it at this time.
- 21:09It's when it works for you. So one of the conversations that
- 21:14we're having a lot on the show is talking about personalization
- 21:18in aesthetics. Everybody wants personalized
- 21:20treatments. How does plated adapt to
- 21:23different skin needs or treatment plans right now or
- 21:26maybe even more in the future? So you know, personalization
- 21:30comes from the fact that you're using human derived ingredients,
- 21:33right, because it's smarter technology, because that power
- 21:36of the human body is incredible and what it can do.
- 21:38I think we've all seen that. So that's really the
- 21:40personalization. What we've seen in our clinical
- 21:41trials is those that are worried about the appearance of brown
- 21:44spots or wrinkles or luminosity, like it really depends on what
- 21:47your skin needs and the technology is smart enough to
- 21:50kind of address those things. So a lot of people have been
- 21:52able to simplify their routine. They don't have to use ten other
- 21:55things. They really can use the plated
- 21:57as the foundation and then just add the other areas where they
- 22:00really feel it's important, additional moisturization or you
- 22:03know the retinoid as we talked about things like that.
- 22:06Now, I did a little bit of research on the global
- 22:10perception of regenerative aesthetics, and it looks like
- 22:14there's regulations and different attitudes and vibes
- 22:18about regenerative aesthetics in other countries.
- 22:21How do you feel that's influencing the innovation here
- 22:24in the US? So I don't think it stopped us.
- 22:26I mean, we have the best scientists in the US and really
- 22:30are advancing things from here. If you think about how many
- 22:32things start in the US and then it goes to other countries.
- 22:35And so I think we're going to see a lot of this continuing,
- 22:38just like we have with other aesthetic things.
- 22:39Like Botox got his first approval in the US, right?
- 22:43And it went to other countries and grew from there.
- 22:45And, you know, at the time was very controversial.
- 22:47So I think this just becomes a thing of education.
- 22:50I think bureaucracy in some of these countries takes a while to
- 22:52catch up with the ideology. So people may be really
- 22:55interested, but maybe the bureaucracy hasn't caught up to
- 22:57kind of understand what's possible.
- 23:00Agreed. Regulations in different
- 23:02countries, very interesting to read about, right.
- 23:05So I heard in the beginning you were talking about different
- 23:08innovations. We would love to know what's
- 23:11coming in 2026 for the company. What is plated look like in
- 23:152026? What are your thoughts on that?
- 23:18Well, we are going to continue to innovate.
- 23:19We've gotten all kinds of ideas. I think I mentioned earlier,
- 23:22we're doing a hair study and in the hair study we're actually
- 23:24treating the eyebrows because patients are super interested,
- 23:27but we have no data to support that.
- 23:30So I'll be really excited to get the data because again, we
- 23:33develop and put the plated name on things that work.
- 23:35And so when we know it works, then we'll get behind it and
- 23:37have something there. So hopefully we'll have that
- 23:39later this year. So I'm really excited and I'm
- 23:41excited about a certain subset of women just really focused
- 23:44people forget about postpartum and post menopausal women and
- 23:47hair loss. So I love that we're studying
- 23:48this particular segment to see how plated hair can really help
- 23:52them. A lot of people asking about
- 23:54body, you know, as you get older, you're a little worried
- 23:56about your arms and your legs and your knees.
- 23:58So we may have a little something up our sleeve there.
- 24:01And I think we're continuing to address this idea that, you
- 24:04know, how do you make sure your face is ready for exosomes,
- 24:07right? How do you enhance what you're
- 24:09doing? You're spending all this money
- 24:10on this incredible product, but like I was doing with these
- 24:13Neutrogena wipes, I was probably destroying 50% of what I was
- 24:16doing. So we're working on some really
- 24:17cool ideas there as well to make sure we enhance the axisoms.
- 24:21I love that. You're working on body.
- 24:23I joke about my elbows all the time because it's a shocking
- 24:27thing to look at when you get to get to my age and you're like,
- 24:30how'd that happen? Whose elbows are those?
- 24:32So I think it's great for us to have options for the body.
- 24:35I think that's something that's been neglected for a little
- 24:37while. Yeah, we're really excited.
- 24:40So when you evaluate plated in the real world, what does that
- 24:45look like? What kinds of feedback or
- 24:47results matter most to you? Well.
- 24:49We're looking for raving fans. And I think what I get excited
- 24:53about is we only have like 12 to 14 ingredients, depending on the
- 24:56product. And most skin care companies
- 24:59have forty ingredients. So what I love is that this is
- 25:01good for so many people, right? Because we don't have all these
- 25:04other things. If you're sensitive to A or B or
- 25:06C, you can't use things. So that's what's been really
- 25:09exciting and just seeing the differences and the feedback and
- 25:13just, I love that we're creating something that people really
- 25:16feel is making a difference because nobody likes to use
- 25:18stuff. And then we all have like you
- 25:19open the drawer, you know, my husband's like, what is all the
- 25:21stuff you have? I'm like none of it worked.
- 25:23So it's. Great to have something having
- 25:25remarkable results. And you know, it's so fun to see
- 25:28us build this category, right? Like we've created an entire
- 25:31category. Now we have all these people
- 25:32joining us. So what an incredible compliment
- 25:35that Plated has been the leader here and setting the bar high.
- 25:38I mean, I hear about it all day long in the industry.
- 25:41And also results speak for themselves, right?
- 25:44When people get great results, then they talk about it and they
- 25:46want other people to know about it.
- 25:48On that topic, obviously innovation and aesthetics moves
- 25:53very fast. How do you decide which trends
- 25:56or technologies are worth investing in and which ones to
- 25:59ignore at this point? Yeah.
- 26:01We spend a lot of time listening to our customers.
- 26:03I think that's really important. And the providers, these
- 26:05providers are in front of people all day long and they have
- 26:09launched so many more products than I have and seen everything
- 26:12from really successful to really bad.
- 26:15And so we try to spend a lot of time, we do advisory boards,
- 26:18we're out in the field, we're small, so we can be nimble and
- 26:21we can pivot and we can really actually listen.
- 26:23You know, when I worked in big corporations, like it's very
- 26:26hard to move and pivot, but now we're small, somebody wants to
- 26:29change something and we agree it's a great idea.
- 26:31We do it. We don't need 50 committees and
- 26:3320 meetings like it's done. And so that's what's been so
- 26:35fun, is being able to listen and hear the feedback and then
- 26:38actually implement it very quickly.
- 26:40And companies that move fast always win, right?
- 26:42If it takes six months and 40 meetings to, you know, make a
- 26:46decision, and it never works. So moving fast is key.
- 26:50So what excites you the most about what's coming in
- 26:53regenerative medicine in general?
- 26:55There's so much conversation about it.
- 26:57What excites you the most about our future?
- 27:00Well, I mean, I think regenerative medicine is going
- 27:02to change the way we treat people, right?
- 27:04I mean, I've worked in the Pharmaceutical industry for so
- 27:06long and you know, I worked in schizophrenia and Women's
- 27:09Health. They worked in orthopaedics.
- 27:11And I guess over the years I've just seen so many adverse
- 27:13events. And so even as a consumer,
- 27:14myself and even my mom, she just had hip surgery at Mayo and I
- 27:18was so worried about what drugs they're going to put her on and
- 27:21what side effects she's going to have and all that.
- 27:23So like, I love the idea of regenerative medicine and that
- 27:26we're using the power of the human body to heal someday.
- 27:29And so to me, that's just absolutely incredible.
- 27:32And the fact that we can hopefully like Reon Medical has
- 27:35shelf stable, right? So you don't have to go in and
- 27:37spin the blood and worry that one day or didn't do well.
- 27:40You know, as we get older, our exosomes aren't as good.
- 27:43So there's a value in like this idea of pooled exosomes.
- 27:47And I think that it's really going to change healthcare.
- 27:50And again, nothing wrong. I love the Pharmaceutical
- 27:51industry, but I think this is going to be a big step for we
- 27:54talk about longevity, right? Like, think about how many times
- 27:57side effects are actually the cause of someone's demise versus
- 28:01the illness itself, you know? Yes, absolutely.
- 28:05Alyssa, it sounds like you have lit this company on fire and
- 28:09done some amazing things. When was the first day that play
- 28:12did really started? So how many years would you say
- 28:15you have into this now? So we're just a little close to
- 28:18four, yeah. Wow, Congrats on all that
- 28:20success. So when people look back on your
- 28:24work, what do you hope they remember about how you change
- 28:26the industry? I hope they remember we did it
- 28:29with integrity and science so we can be proud of what we did.
- 28:33We did it the right way. We didn't care about the next
- 28:36sale. We care about building something
- 28:37that was going to be here a long time.
- 28:39Like I always tell the team, I would rather lose than win the
- 28:42wrong way. I love that.
- 28:44That's a great way to sum things up and wrap up our conversation.
- 28:49It was amazing and I think the brand is great.
- 28:51I love that I'm now having a chance to use these products.
- 28:54I'll probably want a bunch more, but this is amazing.
- 28:57So Congrats on all of your success and if you have a few
- 29:01more minutes, we'd love to keep you here for the speed round.
- 29:04I can't wait. So Alyssa, what is the first
- 29:07thing you do when you wake up? Feed the dogs.
- 29:09I love my dogs. Actually, I let them out.
- 29:12I let them out as the. OK, how many dogs do you have?
- 29:14I have 3 rescues. What is the most used app on
- 29:17your phone right now? Probably.
- 29:20Instagram. Are you an early morning thinker
- 29:22or a late night problem solver? Oh, early morning.
- 29:26I'm a disaster at night. What's 1 luxury as ACEO that you
- 29:30will never apologize for? When I get upgraded for free to
- 29:33business class when I'm flying. What is your superpower as a
- 29:37leader? My energy.
- 29:39Like positivity or energy. Like you are never tired.
- 29:44Yeah, it's just perseverance. Like, I don't like to give up
- 29:46and, and I think hopefully the team would say that, you know, I
- 29:49really try to have their back. If you weren't in aesthetics,
- 29:53what industry do you think you would be shaking up instead?
- 29:56Well, as I get older, this orthopedic industry is becoming
- 29:59much more interesting to me. I worked in it years ago, so I
- 30:02want to go back and change it with regenerative medicine.
- 30:04Less implants and more regenerative medicine early so I
- 30:07don't have to have hips and knees and all the things I've
- 30:09seen all my relatives get. Would you say you are a quick
- 30:12decision maker or chronic overthinker?
- 30:14Quick decision maker. What's the most uncorporate
- 30:17thing about you? Unfiltered.
- 30:20What's one word that your team would use to describe your
- 30:23leadership style? Casual when you hit a wall, what
- 30:27is your go to to reset? I love to get perspective and I
- 30:31take the dogs on a walk and I turn my phone off and I just
- 30:34give myself time to think. Like, perspective is so
- 30:37important and sometimes you get upset about things, but it's
- 30:39good to just walk away. What is 1 product that's not
- 30:42from your own line that you cannot live without?
- 30:45I love the color science SPF brush the powder.
- 30:49I have like 10 of them. They go with me everywhere, it's
- 30:52so great. That's great.
- 30:54When I find something I love, I buy them up too.
- 30:56I put them everywhere so I don't have to think about it anymore.
- 30:59What motivates you more, fear of failure or vision of success?
- 31:04Vision of success I think you should fail a lot and be proud
- 31:08of the failure. When you walk into a room, what
- 31:11is the first thing you want people to feel from you?
- 31:14Empathy. If someone shadowed you for a
- 31:16day, what would surprise them the most about you?
- 31:19I never stop. They'd be exhausted.
- 31:21That's what they tell me. Heels are sneakers.
- 31:25Sneakers all day long. What's 1 beauty product that you
- 31:28always have in your purse? I think it's still the color
- 31:31sign. So chapstick is the other one.
- 31:33I'm addicted to chapstick. Yeah, once you're addicted,
- 31:36there's no there's no getting away from it, right?
- 31:39I have it everywhere, too. Do you hit the snooze or get up
- 31:42right away? Right away.
- 31:44And what time is that in the morning?
- 31:45Early. I usually wake up even before my
- 31:47alarm, so usually like 6, sometimes five.
- 31:50I'm an early bird. What's the last show that you
- 31:53binge watched? I usually love crime shows but
- 31:56I've been watching Nurse Jackie lately on Netflix.
- 31:58But typically I'm a crime showgirl.
- 32:00Do you answer emails at midnight or wait until the morning?
- 32:04Midnight on, sometimes 3 in the morning too.
- 32:06OK. I'm awake and I'm thinking of
- 32:08it, but I don't expect my team to answer at the same time.
- 32:10That's the most important thing they have to understand.
- 32:12Just 'cause I have crazy hours doesn't mean they do.
- 32:15What's one thing you've learned to say no to without any guilt?
- 32:18Travel. What instantly makes you lose
- 32:21your? Patience, inefficiency.
- 32:24Now we're. Going to go and talk about some
- 32:26industry topics, OK. Yeah, All right.
- 32:29Preventative neurotoxin in or out?
- 32:31In. At home, red light masks in or
- 32:34out. In have several.
- 32:36Wellness Ivs offered at Med spas in or out.
- 32:39Not ready yet? On the fence.
- 32:41Facials with exosomes in or out. I use facials and then are
- 32:46plated exosomes, not just any. At home micro needling rollers.
- 32:51Out. Collagen drinks and powders.
- 32:54Out. Combining exosomes with RF micro
- 32:58needling. No out.
- 33:00Skin tightening threads, PDO threads.
- 33:03Out. AI beauty diagnostics.
- 33:05In I love AI. It's AI or die.
- 33:08That's what I tell the. I love it.
- 33:10Couldn't agree more. If we're not doing it, we're
- 33:12falling behind. Beauty supplements replacing
- 33:16topicals. Out.
- 33:19Skin flooding hydration trend. Out.
- 33:23Injectable skin boosters. In.
- 33:25Peptide rich serums. In.
- 33:28Copper Peptides. Out retinal I'd have to say I
- 33:33don't use it anymore, so out. Growth Factor.
- 33:36Skin care. Out.
- 33:38Overnight resurfacing masks. Out.
- 33:41Niacinamide in everything. Out.
- 33:44Exfoliating toners. Exfoliators, yes, not
- 33:48necessarily toners. Fermented ingredients.
- 33:51No out. Well, Alyssa, thank you for
- 33:54giving us the chance to get to know you in the speed round and
- 33:56get your opinions on some of the hottest topics in the industry.
- 34:00So that's great. We love to hear that and thank
- 34:03you so much for joining us today.
- 34:04Is there anything else that you'd love to leave our audience
- 34:06with? No, I just appreciate what
- 34:08you're doing. We love education and you're
- 34:10doing a great job, so keep it up.
- 34:12Well, thanks so much for joining us and thank you for sharing
- 34:14your amazing line. I look forward to diving into it
- 34:16even deeper. And to our listeners and
- 34:19viewers, thank you for tuning into the Doctor Randy show,
- 34:22where we are redefining what's next, one conversation at a
- 34:25time. See you next week.
- 34:27Doctor Randy Boyett holds a PhD and is a recognized leader in
- 34:31the aesthetics and medical industry.
- 34:33She is not a licensed medical doctor.
- 34:36All commentary and product recommendations are based on
- 34:39industry expertise and are provided for informational
- 34:42purposes only.