1193-Mapping MDD Risk Genes via In Vivo Perturb-seq Analysis
Researchers have developed a sophisticated in vivo AAV-Perturb-seq platform to investigate the biological functions of major depressive disorder (MDD) risk genes within the mouse brain. By performing high-throughput loss-of-function screening on dozens of candidates identified through human genetic studies, the team successfully mapped how these genes influence neuronal gene expression and synaptic signaling. Their analysis pinpointed a specific MDD risk cluster, featuring the gene Dennd1a, which produces a transcriptomic signature remarkably similar to those found in human patients…
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