Why Your NAD+ Supplement Might Not Be Working
New research reveals that NAD+ supplementation effectiveness depends less on total NAD+ levels and more on the NAD+/NADH ratio—the balance between oxidized and reduced forms. This mechanistic finding suggests current longevity protocols using NMN and NR may miss critical metabolic outcomes unless combined with redox-balancing compounds like ubiquinol, fundamentally shifting how aging-focused supplement strategies should be designed.
The skinny
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