1697-Ageing Promotes Lung Cancer Metastasis

Paper Talk · Oct 22, 2026 · 23m

The research investigates how physiological ageing reshapes the evolutionary trajectory of KRAS-driven lung adenocarcinoma, revealing that older subjects experience reduced primary tumor growth but a significantly accelerated rate of metastatic dissemination. Through comprehensive transcriptomic and epigenomic analyses, the study demonstrates that tumor cells in aged environments exhibit persistent activation of the integrated stress response (ISR) driven by the master transcriptional effector ATF4. This age-associated ATF4 signaling axis confers crucial epithelial-mesenchymal transition…