1457-MRPL3 Driven Early Hepatocellular Carcinoma Recurrence
This scientific study identifies the mitochondrial protein MRPL3 as a primary driver of early recurrence in hepatocellular carcinoma (HCC). Through proteomic profiling, researchers found that high levels of this protein correlate with poor patient survival and increased tumor aggression. Mechanistically, MRPL3 stabilizes TOMM40, which activates the PGC-1α/TFAM signaling pathway to enhance mitochondrial energy production and respiration. Experimental results demonstrate that silencing this axis reduces the ability of cancer cells to proliferate and migrate. Ultimately, the findings suggest…
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