1438-PGE2-Driven Dendritic Cell Dysfunction in Breast Cancer
This research article explores how prostaglandin E2 (PGE2) causes immune evasion in breast cancer patients with skin involvement. By analyzing patient tissues and mouse models, the study identifies that high levels of this metabolite impair the activation of dendritic cells, preventing them from effectively priming T lymphocytes to attack the tumor. Clinical data indicates that low dendritic cell activity and high PGE2 levels are linked to worse survival outcomes and poor treatment responses. The authors demonstrate that blocking PGE2 or its synthesis via inhibitors like celecoxib can…
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