593-VCWorld: A Biological World Model for Virtual Cells
The paper introduces VCWorld, a novel "white-box" biological simulator designed to predict how cells respond to drug perturbations. Unlike traditional "black-box" AI models that lack transparency, VCWorld integrates a biological world model with the reasoning power of Large Language Models to provide interpretable, step-by-step mechanistic explanations. The system utilizes a structured knowledge graph—combining data from sources like DrugBank and Gene Ontology—alongside a specialized retrieval mechanism to anchor its predictions in established scientific facts. To support this framework, the…
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