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The Antidepressant That Vomited Its Way Toward Being a Psychedelic
The Antidepressant That Vomited Its Way Toward Being a Psychedelic
A forgotten drug from 1966 behaved like a true psychedelic in animals yet produced projectile vomiting in monkeys and severe gastrointestinal distress in humans at 25 mg - so how could the same molecule show LSD-like head-twitches and still fail to produce visions in people? What if a single receptor blockade could have unlocked its psychedelic effects?
In this episode, we trace the published record from the first syntheses through animal conditioning studies, receptor pharmacology, and halted human exposure to ask whether…
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