Latest / The Bill Handel Show / Time to Ditch Coffee | ‘Medical News’ with Dr. Jim Keany

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Time to Ditch Coffee | ‘Medical News’ with Dr. Jim Keany · The Bill Handel Show

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Speaker 1: You're listening to Bill Handle on demand from KFI AM
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Speaker 1: six forty.
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Speaker 2: Fine am six forty handle here on a Wednesday morning.
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Speaker 3: Oh man, we've got we still have plenty to do.
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Speaker 2: By the way, some of the stories we're looking at
0:18
Speaker 2: is the average price for a car has now topped
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Speaker 2: fifty thousand dollars. Isn't that special? Inflation isn't here, not
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Speaker 2: at all? And Kaiser permanity healthcare workers other than doctors
0:33
Speaker 2: are on strike. The nurses, the nurse and ethetists, the pharmacists,
0:38
Speaker 2: they're on strike. And on top of that, what's happening
0:42
Speaker 2: in the Middle East. Hamas once again pulling a bonehead move,
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Speaker 2: and that is not releasing the bodies the remains of
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Speaker 2: the dead hostages.
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Speaker 3: They're supposed to.
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Speaker 2: Release all of them by midnight, Monday night, a long
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Speaker 2: past and so Israel is getting a little upset about it.
1:01
Speaker 2: Already cut aid half the aid coming into Gaza.
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Speaker 3: All right. There is a federal lawsuit that has been filed. California.
1:09
Speaker 2: Governor Newsom signed a bill on glock style pistols, which
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Speaker 2: feature and I'm going to read this from the La Times.
1:17
Speaker 3: I'm sure I'm going to be corrected on this.
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Speaker 2: Allowing the attachment of what is being called by them
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Speaker 2: a machine gun conversion device. And it's a bill that
1:28
Speaker 2: was just signed and prohibits semi automatic pistols with these
1:32
Speaker 2: cruciform trigger bars that enable switches converting guns into rapid
1:40
Speaker 2: fire weapons. Now, the lawsuit, of course claims, as always does,
1:44
Speaker 2: that the band violates a Second Amendment. And there are
1:47
Speaker 2: a couple of very interesting legal arguments here, and one
1:50
Speaker 2: in particular I want to share with you John Cumberford,
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Speaker 2: the executive director of the NRA Institute for Legislative Action.
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Speaker 3: No surprise here.
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Speaker 2: Quote Newsom and his gang of progressive of politicians in
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Speaker 2: California are continuing their crusade against constitutional rights. They are
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Speaker 2: attempting to violate landmarks, Supreme Court decisions, and disarmed law
2:11
Speaker 2: abiding citizen by banning some of the most quote commonly
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Speaker 2: used or owned handguns in America. The word commonly owned
2:20
Speaker 2: is critical to this law, particularly the argument that the
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Speaker 2: NRA and Gun to Have its advocates have so put
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Speaker 2: that in your mind commonly used. All Right, the lawsuit says,
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Speaker 2: of course, violates the Second Amendment. But then anything, anything,
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Speaker 2: any law that somehow limits any kind of weapon instantly
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Speaker 2: gets a lawsuit from gun advocates.
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Speaker 3: You know, it becomes a slope no matter what.
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Speaker 1: You know.
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Speaker 4: What's weird about this, though, Bill that the Okay, so,
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Speaker 4: a glock doesn't have a traditional.
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Speaker 1: Safety system.
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Speaker 4: Most guns have a safety that you put on right
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Speaker 4: and that keeps the gun from triggering. This system is
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Speaker 4: part of the safe action system on a glock. Glock
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Speaker 4: does not have a traditional safety. This whole thing was
3:15
Speaker 4: created so that you couldn't drop the gun and have
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Speaker 4: it go off, so that the striker would not engage.
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Speaker 1: That's why glocks have this in the first place.
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Speaker 2: Okay, Well, let me ask you. I understand that, and
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Speaker 2: I get that part of it. I think I understand.
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Speaker 4: I just think it's weird that it was originally a
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Speaker 4: safety mechanism.
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Speaker 2: It could be, but can it be changed to fire
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Speaker 2: a rapid fire.
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Speaker 1: Any semi automatic?
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Speaker 4: Okay, modifications could become fully audit is it? However, you
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Speaker 4: wouldn't want a fully automatic handgun.
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Speaker 1: You couldn't control it.
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Speaker 2: It doesn't matter. The Supreme or the NRA is arguing
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Speaker 2: that any limitation. You see, we got the slippery slope.
3:55
Speaker 2: So I want to go on and talk about this
3:57
Speaker 2: because this is a really interesting argument that I think
4:00
Speaker 2: actually the gun folks are going to have Supreme Court
4:04
Speaker 2: on their side. So going on with the lawsuit, a
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Speaker 2: law that bans as sale that prevents citizens from acquiring
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Speaker 2: a weapon in common use violates.
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Speaker 3: A second Amendment. That's the other issue.
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Speaker 2: If it's in common use, therefore it is constitutionally protected.
4:26
Speaker 2: They even agree that a gun that is incredibly dangerous
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Speaker 2: should not be used. I'm assuming machine fifty caliber machine
4:34
Speaker 2: guns are part of that. But if there's a law
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Speaker 2: banning machine guns, I'm sure they would argue that. And
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Speaker 2: I understand there's been a lawsuit file by the NRA
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Speaker 2: that the prohibition against eighty eight howitzers, the automatic bazookas. Yes, yes,
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Speaker 2: that those laws are unconstitutional, of course, but here it
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Speaker 2: is the argument is that they are, and this is there.
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Speaker 2: They are unquestionably in common use for lawful purposes. In fact,
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Speaker 2: they're among the most popular handguns in the nation. And
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Speaker 2: we're talking about glocks now. The guy who introduced Jesse Gabriel,
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Speaker 2: who introduced the bill in California, and here I'm gonna
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Speaker 2: quote him, automatic weapons are exceptionally lethal. I'll buy that
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Speaker 2: capable of firing hundreds of rounds per minute. Don't know
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Speaker 2: about that, and they're illegal in California. That's correct. Unfortunately,
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Speaker 2: some semi automatic fire guns feature a dangerous design element
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Speaker 2: allowing them to be converted to automatic weapons. And here,
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Speaker 2: I think is the issue, because any gun can be modified.
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Speaker 2: But this is an easy to use device known as
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Speaker 2: a switch. You can simply buy it on the internet
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Speaker 2: and install it in minutes, and.
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Speaker 1: You have a gun that's quite honestly, but hardon.
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Speaker 4: Let me ask you this, A handgun in California can't
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Speaker 4: have more than I think eight rounds or something in
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Speaker 4: the magazine under.
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Speaker 1: Eight rounds.
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Speaker 3: That's the thing.
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Speaker 1: Though a fully automatic eight rounds is a second right.
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Speaker 3: It does it just shoots. A matter of fact, I
6:06
Speaker 3: would and I don't know.
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Speaker 1: That this is not a good automatic weapon.
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Speaker 3: I understand it's not a good automatic weapon.
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Speaker 2: It's probably less lethal than a single shot because you
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Speaker 2: don't aim, you can't control it. You just press the
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Speaker 2: trigger and the bullets come flying out.
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Speaker 4: You're spitting out shot an automatic weapon, and I have
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Speaker 4: a fully automatic weapon.
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Speaker 1: It is hard to control even as a rifle.
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Speaker 2: Okay, guy understood that is Actually there's an argument there
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Speaker 2: that when you combine the fact that you only have
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Speaker 2: eight bullets in a magazine and when you have a
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Speaker 2: gun that is fully automatic, that makes it actually safer
6:48
Speaker 2: for someone.
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Speaker 3: Who's gonna get shot.
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Speaker 2: Then the other way that is, yeah, you're actually arguing you,
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Speaker 2: I'd rather have that if someone's gonna shoot it.
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Speaker 1: No one's going to be able to control it.
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Speaker 3: Right.
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Speaker 2: Uh So the argument is, and here's the argument that
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Speaker 2: I use because it's a fun legal argument we can order.
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Speaker 2: The technical part all the time is that the court
7:06
Speaker 2: has said guns that are in usual usage, if they're
7:11
Speaker 2: usually used by the population, then the Second Amendment applies.
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Speaker 2: And what the NRA is saying that most of the
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Speaker 2: guns out there can easily be converted, which may very
7:23
Speaker 2: well be true. And so what's going to end up
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Speaker 2: happening is the court is going to rule on it.
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Speaker 2: Because when you think about the court ruling, it basically
7:30
Speaker 2: is a Heller decision coming out of Detroit. You could
7:33
Speaker 2: have a handgun to protect yourself in your house. That's
7:37
Speaker 2: where it started with the laws against guns. Handgun to
7:43
Speaker 2: own or to modify the weapon. Yeah, the problem is, yeah,
7:48
Speaker 2: it is legal. And then the issue became remember the
7:51
Speaker 2: what we call it the gun modification that was used
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Speaker 2: in a commandal a.
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Speaker 1: The with the modified bump stock.
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Speaker 3: Yeah, the bump stock.
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Speaker 1: Yeah, but you can do that without anything.
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Speaker 4: You could do that with your finger and your thumb
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Speaker 4: in your belt.
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Speaker 3: You can't make them that. Well, the argument was could
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Speaker 3: you do it that quickly? I don't know.
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Speaker 2: But here is the issue is here, and I look
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Speaker 2: at the constitutional arguments, I look at what the court
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Speaker 2: has said, and that is usual usage.
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Speaker 3: And I guess, no matter.
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Speaker 2: What is going to be constitutionally protected. Clarence Thomas is
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Speaker 2: the nutcase on this agree and that is we have
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Speaker 2: to look at it historically. And historically everybody had a
8:38
Speaker 2: gun and use it during the Civil War, well not
8:42
Speaker 2: Civil War era, but during the revolutionary times when we
8:46
Speaker 2: created a country. So let's look at gun ownership in
8:50
Speaker 2: reference to back then. What It's a different world, guys,
8:55
Speaker 2: certainly Clarence Thomas. Anyway, I thought it was an interesting
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Speaker 2: bit of legality or legal news regarding guns.
9:02
Speaker 3: Okay, let's talk about another.
9:04
Speaker 2: Product that costs a whole lot more money, and that
9:07
Speaker 2: is coffee. Oh yes, even before the US imposed tariffs
9:12
Speaker 2: of fifty percent on Brazil and politics of that is
9:15
Speaker 2: crazy twenty percent on Vietnam. The two countries Brazil and
9:19
Speaker 2: Vietnam together produce more than half of the world's coffee beans.
9:24
Speaker 2: And so you have the tariffs in the way. Then
9:28
Speaker 2: you have climate change, the related fires which really doesn't
9:32
Speaker 2: exist of course, flooding, droughts, droughts, all of it affecting
9:36
Speaker 2: coffee prices up.
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Speaker 3: Coffee in the US today.
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Speaker 2: Is nearly forty percent more expensive than it was a
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Speaker 2: year ago. Now I buy coffee in bulk, so actually
9:51
Speaker 2: Lindsay buys the coffee for me. So I don't pay
9:53
Speaker 2: attention because frankly, I don't care. If I don't have
9:56
Speaker 2: my coffee in the morning, I'm done. I'm just done.
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Speaker 2: Fin You know that's to me, it's desperation time if
10:04
Speaker 2: I don't have coffee. So it's forty percent more, okay,
10:07
Speaker 2: If it's twice more, if it's one hundred percent more,
10:10
Speaker 2: I'm okay. I noticed Amy has her coffee cup with
10:14
Speaker 2: her right now. I notice that Neil when he comes on,
10:17
Speaker 2: he has his espresso. I have my coffee cup. I
10:20
Speaker 2: do two big big cups of coffee.
10:24
Speaker 4: A schedule, so it gets delivered all the time, that
10:28
Speaker 4: it won't break schedule.
10:29
Speaker 2: We always have my coffee here. Now it's a story
10:33
Speaker 2: out of the Atlantic. Coffee has no nutritional value. You
10:37
Speaker 2: can replace caffeine with almost anything out there. Walking to
10:43
Speaker 2: a gas station. How many caffeine supplements you know, monster,
10:46
Speaker 2: et cetera.
10:47
Speaker 3: Do we you have?
10:49
Speaker 2: So we definitely desperately not need it, but we want it.
10:55
Speaker 2: It's fixed in our culture, our economy, our rituals, our
10:59
Speaker 2: brain chemistry. It's the most consumed beverage outside of water,
11:06
Speaker 2: and caffeine is by far the most popular drug on earth.
11:11
Speaker 2: And on any given day, an American is or likeli
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Speaker 2: or to drink coffee than they are to exercise, No kidding, pray.
11:19
Speaker 3: How about praying while drinking coffee?
11:21
Speaker 2: Does that work? I don't pray a lot or reading
11:25
Speaker 2: for pleasure. There are more Starbucks than public libraries in America.
11:31
Speaker 2: And as a matter of fact, it's so crucial that
11:35
Speaker 2: most employers give it away in the office.
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Speaker 3: They just give it to you.
11:40
Speaker 2: You go to the coffee station. We of course have coffee.
11:43
Speaker 2: I've never worked in an office. A few times I've
11:45
Speaker 2: worked in office, didn't have coffee available for everybody. You know,
11:51
Speaker 2: iHeart produces. Of course, this building produces coffee. Not on Yeah,
11:55
Speaker 2: on our floor, we have coffee, that's a given. Upstairs
11:58
Speaker 2: they give you free drinks too, and snacks, you know that.
12:00
Speaker 2: But we're on the fourth floor, not on the fifth floor.
12:03
Speaker 2: AM is not the same as FM. That's an aside
12:06
Speaker 2: I just want to throw out there. But the bottom
12:09
Speaker 2: line is that we are in trouble because of the
12:13
Speaker 2: price of coffee, and it doesn't look like it's getting
12:17
Speaker 2: any cheaper anytime soon. Amy, have you noticed the price
12:21
Speaker 2: of coffee? Has that occurred to you or you just
12:23
Speaker 2: don't care and don't pay attention.
12:25
Speaker 3: I pay attention, but it doesn't matter.
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Speaker 1: It doesn't stop me from drinking coffee.
12:29
Speaker 2: But I do notice at the store that it costs
12:32
Speaker 2: more and there are fewer sales.
12:35
Speaker 3: Okay.
12:36
Speaker 2: Also, Maxwell House has come back. I mean, what you know,
12:39
Speaker 2: freeze dried coffee? I mean, what the hell is that about, Neil,
12:42
Speaker 2: Have you noticed the cost of coffee has gone up?
12:45
Speaker 1: Absolutely?
12:46
Speaker 2: Okayly, of course, that doesn't stop you from buying the
12:49
Speaker 2: same amount of coffee.
12:50
Speaker 4: Oh, we're very very specific on what we drink here
12:54
Speaker 4: and what we like, and we'll pay whatever for it.
12:57
Speaker 3: Okay. See, what's the whole point.
13:00
Speaker 1: Uh, we drink.
13:01
Speaker 4: We have an espresso and we drink cafe the Jave,
13:05
Speaker 4: which is made from the Don Francisco folks.
13:07
Speaker 3: We love Don Francisco.
13:09
Speaker 1: It's just excellent. Their espresso is fantastic.
13:12
Speaker 2: Also, I'm in an espresso person too, love that machine.
13:15
Speaker 2: Kno drink coffee?
13:17
Speaker 3: No, thank you? Wow your unusual? Uh will you drink coffee? Oh?
13:22
Speaker 5: Yeah?
13:23
Speaker 3: Okay? Have you noticed? Have you noticed the price has
13:25
Speaker 3: gone up?
13:26
Speaker 2: You know, I haven't paid attention, but I did make
13:29
Speaker 2: the switch, though I don't. I try not to do
13:31
Speaker 2: the actual like Starbucks or pizza or anything I go.
13:34
Speaker 2: I just buy it at the store and make it
13:35
Speaker 2: at home. Oh absolutely, Starbucks. I hate Starbucks coffee. It's
13:39
Speaker 2: too bitter for me. I just don't like it.
13:41
Speaker 1: I'm not a fan either.
13:42
Speaker 3: Yeah, I like. I like mine at home too. And
13:45
Speaker 3: you're a coffee person, Yes, absolutely, but I make it
13:49
Speaker 3: a home. We just buy the little we have a
13:51
Speaker 3: cure egg and we just buy the little the box
13:53
Speaker 3: of the margin Eric noticed. Yeah, notice absolutely, Yeah, and
13:58
Speaker 3: doesn't stop you. I mean I think that's the point.
14:00
Speaker 2: No, there's they're still selling all all the coffee that
14:04
Speaker 2: they can grow. It doesn't stop, all right, Doctor Jim Keeney,
14:08
Speaker 2: it's our medical segment, chief medical officer for Dignity Saint
14:13
Speaker 2: Mary Medical Center in Long Beach.
14:14
Speaker 3: I Jim, good morning, yep, good morning. I know, oh
14:17
Speaker 3: there you are, all right? Uh okay. One of my
14:20
Speaker 3: favorite topics that we talk about.
14:21
Speaker 2: Of course, constipation is just one of those things. And uh,
14:25
Speaker 2: you know a lot of us deal with constipation. A
14:27
Speaker 2: lot of us have successfully dealt with constipation, for example,
14:33
Speaker 2: going to federal prison for a few months.
14:35
Speaker 3: Now.
14:37
Speaker 2: See I got you on that one, didn't I uh,
14:42
Speaker 2: all right, uh a, I guess not a cure, but
14:46
Speaker 2: certainly I help for constipation. Kiwis like the kiwi's that
14:50
Speaker 2: you put in the fruit.
14:53
Speaker 5: Yeah, exactly, So like kiwi's. They're similar to I think
14:57
Speaker 5: an American culture. You know, prof uns are more well known,
15:01
Speaker 5: but you know they trigger, you know, increase volume of
15:06
Speaker 5: water drawn into the gut because of the amount of
15:09
Speaker 5: sugar that's in kiwi's and in prunes. And then that helps,
15:13
Speaker 5: you know, helps things move along because it's stays more hydrated.
15:17
Speaker 5: It actually triggers bowel contractions too, so and it makes
15:20
Speaker 5: the stool more soft. So all you put all that together,
15:23
Speaker 5: and basically kiwis will help, and the studies show that
15:27
Speaker 5: they're so effective kiwis and prunes that rather than promoting
15:31
Speaker 5: like fiber supplements or other supplements or even probiotics or medications,
15:36
Speaker 5: that doctors should use this. This is the British you know,
15:40
Speaker 5: health system. By the way, they said doctors should use
15:42
Speaker 5: this as first line therapy rather than other things, and
15:45
Speaker 5: I think that's a good idea, right because it's a
15:47
Speaker 5: little bit more natural. They're even saying, you know, mineral water.
15:50
Speaker 5: They call it in mineral water because compared to electrolyte
15:54
Speaker 5: waters and things like that, electrolyte waters usually are high
15:56
Speaker 5: and potassium and that replaces you know, what you lose
15:59
Speaker 5: when you sweat a bit. But mineral water is usually
16:02
Speaker 5: rich in magnesium, and magnesium helps. It has a mild
16:06
Speaker 5: lacksative effect, It helps your gut move better, helps you
16:09
Speaker 5: sleep at night. So a lot of good, you know,
16:12
Speaker 5: good effects from using a magnesium supplement or drinking magnesium
16:16
Speaker 5: rich mineral water have there.
16:19
Speaker 2: I'm assuming there are studies out there that compare prison
16:22
Speaker 2: with kiwis and which would you suggest.
16:27
Speaker 5: Yeah, No, I don't think there's any studies out there
16:29
Speaker 5: to compare.
16:31
Speaker 2: Oh okay, here is a big story that's very serious,
16:36
Speaker 2: which I think is groundbreaking. The FDA is clearing a
16:41
Speaker 2: blood test for Alzheimer's. Prior to this that there was
16:45
Speaker 2: nothing there other than the symptoms.
16:47
Speaker 5: Right, No, we actually we talked about a blood test
16:53
Speaker 5: just back in March that is a different type of
16:57
Speaker 5: blood test, but also as by the FDA that to
17:03
Speaker 5: look for the products that are related to Alzheimer's that
17:07
Speaker 5: you find in the blood. So what this is is
17:10
Speaker 5: it's not really a test to determine you have Alzheimer's.
17:13
Speaker 5: It's a test to really rule out Alzheimer's, right, if
17:15
Speaker 5: this test is negative, this especially this new one. So
17:18
Speaker 5: what they're looking for we talked about Alzheimer's. What it is.
17:23
Speaker 5: It's a combination of what we call amyloid plaques, which
17:27
Speaker 5: is a bunch of gunk that gets in between the nerves,
17:31
Speaker 5: and then there's tawel proteins that tangle within the nerve
17:35
Speaker 5: fibers themselves and cause bad conduction of nerves of electrical signals.
17:41
Speaker 5: So the taul protein can be found in the blood
17:45
Speaker 5: in these people that are developing Alzheimer's disease. And the
17:49
Speaker 5: steps are in that order. It's first the amyloid, then
17:51
Speaker 5: the twel and so once you find that in the blood,
17:54
Speaker 5: you're concerned that they may have Alzheimer's. It's not diagnostic.
17:58
Speaker 5: You then need to go on to the diagnostic tests.
18:00
Speaker 5: But if this test is negative, if you have somebody
18:02
Speaker 5: coming in, say they have a strong family history of Alzheimer's,
18:05
Speaker 5: they're getting memory loss early in life, and then they
18:08
Speaker 5: get a negative test, this test is said to be
18:11
Speaker 5: ninety eight percent accurate in ruling out Alzheimer's disease.
18:16
Speaker 2: When you talk about memory loss early in life, what
18:21
Speaker 2: does early mean?
18:24
Speaker 5: So if your we typically look at this and this
18:27
Speaker 5: test would be for people fifty five and over, and
18:30
Speaker 5: so if you're having memory loss before fifty five, that's
18:33
Speaker 5: very concerning and probably is not Alzheimer's. It could be
18:36
Speaker 5: it could be a variant of Alzheimer's, but that's something
18:40
Speaker 5: that needs to be looked into by a neurologist typically.
18:43
Speaker 2: All right, by the way, is Alzheimer's is it increasing
18:48
Speaker 2: or is just the diagnostics are improving?
18:52
Speaker 5: You know a good question. I think that that both
18:55
Speaker 5: you know that it may be increasing slightly. I don't
18:57
Speaker 5: have the stats on that, but for sure are ability
19:00
Speaker 5: to diagnose it as improving. And now before we had
19:04
Speaker 5: to make the diagnos diagnosis clinically right, people would come
19:07
Speaker 5: in with certain features and we would attribute it to
19:09
Speaker 5: Alzheimer's disease. Now we actually have the ability to measure
19:13
Speaker 5: things like MRIs and look for amloiacks neurofibrillarity tangles, and
19:19
Speaker 5: this can confirm that the person's developing Alzheimer's. Uh.
19:23
Speaker 2: Yeah, it's pretty scary stuff. And like, uh, I have
19:27
Speaker 2: memory issues. Uh, there's no question about it. And I'm
19:30
Speaker 2: really concerned. And everybody I know is telling me, handle
19:33
Speaker 2: you've had these memory issues since you've been in your
19:35
Speaker 2: twenties and nothing has changed. And frankly, I've forgotten that
19:41
Speaker 2: I had it in my twenties, So you know at
19:44
Speaker 2: some point.
19:46
Speaker 3: You know, by the way, I'm not far off on
19:47
Speaker 3: that one.
19:48
Speaker 2: So now, next time we get together, you and I
19:51
Speaker 2: will do a little test right there on dementia.
19:55
Speaker 3: I'll do it.
19:55
Speaker 5: Yeah, I'll bring a mini mental status exam and we'll
19:58
Speaker 5: see how you do.
20:00
Speaker 4: Uh.
20:00
Speaker 2: Liver disease, that's always fun to talk about. One of
20:03
Speaker 2: my favorite diseases, liver.
20:04
Speaker 3: Disease and there is a.
20:08
Speaker 2: Breakthrough, and that's dealing with liver disease, not giving you
20:11
Speaker 2: a lead liver disease.
20:12
Speaker 3: Is that fair to say?
20:14
Speaker 5: Yeah, So the breakthrough is, yeah, how to address liver disease.
20:18
Speaker 5: You remember last week we just talked about you know,
20:22
Speaker 5: drinks and sugary drinks and even diet sodas as much
20:26
Speaker 5: as you know, one diet soda a day can increase
20:29
Speaker 5: your risk for liver disease. And this is what's called
20:33
Speaker 5: metabolic dysfunction associated dietotic liver disease or a mass LD.
20:40
Speaker 5: And so that leads to a worsening form of liver
20:43
Speaker 5: disease that can cause permanent damage, cirrhosis, and even liver failure.
20:47
Speaker 5: And up to twenty percent of those cases, and we're
20:49
Speaker 5: seeing a lot more of these. We believe that you know,
20:52
Speaker 5: probably at least forty to sixty percent of the population
20:54
Speaker 5: has the early forms because of all the diet soda
21:00
Speaker 5: as in regular sodas that people are drinking. So this
21:03
Speaker 5: is kind of interesting. Now, remember this was done not
21:06
Speaker 5: on humans, but on rats and deeper fish way, so
21:11
Speaker 5: still not human studies, but good markers that show that
21:15
Speaker 5: the fatty accumulation in the rats liver reverses with these
21:19
Speaker 5: two drugs put together, and then so do all the
21:22
Speaker 5: other metabolic markers in a rat. So I mean I
21:27
Speaker 5: think it's a it's a good start and potentially shows
21:30
Speaker 5: that there's some drugs out there that are These are
21:33
Speaker 5: not FDA approved in the US, by the way, just
21:35
Speaker 5: in other countries they're using these. That one drug is
21:39
Speaker 5: an arb which is used for blood pressure, and the
21:41
Speaker 5: other one is used for triglissrizing cholesterol, and they're being
21:46
Speaker 5: used regularly in other countries. We can repurpose those for
21:49
Speaker 5: something like this, which is great news.
21:52
Speaker 2: Jim, I do pay attention to rat studies idea, this
21:59
Speaker 2: one is a joke. I mean, you have studies that
22:03
Speaker 2: are done, as you indicated in rats and you know whatever,
22:08
Speaker 2: excuse me, So whatever you put into a rat causes.
22:13
Speaker 3: This disease or that disease or cures this disease.
22:16
Speaker 2: I mean you know what in terms of efficacy in humans,
22:20
Speaker 2: do you do?
22:20
Speaker 3: You buy this stuff?
22:23
Speaker 5: Yeah? I mean this this is how research is done,
22:25
Speaker 5: and this is often how we get the first signals
22:28
Speaker 5: that something could be good. You know, for humans, a
22:31
Speaker 5: lot of our metabolic processes really carry over. I mean,
22:35
Speaker 5: rats make cholesterol and they have a liver, so a
22:38
Speaker 5: lot of this is really connected to humans. And when
22:42
Speaker 5: it shows promise in that population and there's a good
22:46
Speaker 5: kind of physiologic reason why this would work, and we
22:49
Speaker 5: have the same exact mechanism in our body, it's a
22:53
Speaker 5: good first step. But of course nobody is going to
22:56
Speaker 5: recommend that we across the board we start mixing these
22:59
Speaker 5: two chemical right. Yeah, but it's a really good first
23:03
Speaker 5: step and it's really encouraging. So you love to know
23:06
Speaker 5: about cutting edge, and this is cutting edge, all.
23:09
Speaker 3: Right, fair enough, but let me let me throw something
23:11
Speaker 3: at you.
23:11
Speaker 2: This would be the last question, and that is as
23:13
Speaker 2: a percentage if a certain drug or procedure works in
23:19
Speaker 2: rats and then translating to humans after the additional testing,
23:24
Speaker 2: what is the percentage of success at the rat level
23:28
Speaker 2: that translates for us.
23:30
Speaker 5: Yeah, that's a lot harder because you're talking about such
23:34
Speaker 5: a wide variety. Again, something like this. I think it's
23:37
Speaker 5: encouraging because there is a lot of conservation of processes
23:41
Speaker 5: between humans and rats in this area, but in other
23:45
Speaker 5: areas maybe not so much. Because I mean, I remember
23:47
Speaker 5: one that was supposed to be a vaccine for ass infections.
23:53
Speaker 5: I thought, wow, this is going to change the world.
23:55
Speaker 5: And it really worked well in rats. It did not
23:57
Speaker 5: work at all in humans. So the immune system is
24:01
Speaker 5: a totally different thing and may not be as well
24:03
Speaker 5: conserved when you go from rats to humans.
24:06
Speaker 3: Got it all right, Jim, Thank you? Well this is
24:08
Speaker 3: again next week.
24:09
Speaker 2: Always good stuff, greatly appreciated. All right, thank you, taking care,
24:12
Speaker 2: I have a good one. All right, we're done, guys.
24:15
Speaker 2: There is a show is done coming up Gary and
24:18
Speaker 2: Shannon tomorrow morning. Amy and will start with wake up
24:23
Speaker 2: call at five o'clock. Neil and I jump in at
24:25
Speaker 2: six to right about now, and then of course we
24:28
Speaker 2: have a Cono and and that make the show run.
24:32
Speaker 2: And if you notice the show many many times does
24:35
Speaker 2: not run, well that's con O and and you can
24:38
Speaker 2: blame them.
24:40
Speaker 3: Well, we'll catch you in the morning.
24:41
Speaker 2: This is KFI AM sixty.
24:45
Speaker 3: You've been listening to the Bill Handle Show.
24:47
Speaker 2: Catch my show Monday through Friday six am to nine am,
24:51
Speaker 2: and anytime on demand on the iHeartRadio app.