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The Senescence Link: How Aging Cells Destroy Male Fertility—and How to Reverse It

A groundbreaking study identifies the exact biological mechanism behind male reproductive decline: senescent cells accumulating in the epididymis actively suppress sperm motility through inflammation. Researchers show this damage is reversible using senolytics, opening a direct pathway from mouse studies to human clinical trials and positioning reproductive aging as an overlooked but targetable frontier in longevity research.

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