1065-A Molecular Blueprint for V3-Glycan HIV Vaccine Design
Researchers have developed an innovative animal model using rhesus macaques to overcome a long-standing hurdle in HIV-1 vaccine design. By utilizing a specifically engineered virus called SHIV.5MUT, the team successfully induced broadly neutralizing antibodies (bNAbs) that target the V3-glycan epitope, a feat previously difficult to achieve in outbred species. This process occurs through a two-step mechanism where an initial wave of antibodies forces the virus to evolve shortened V1 loops, which subsequently exposes the target site to prime the immune system. The study highlights that these…
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