1701-Microglial SPP1-ITGB1 Loop Drives Post-Stroke Pain
Central post-stroke pain frequently arises following thalamic hemorrhage, yet the precise biological pathways driving this debilitating transition from acute injury to chronic discomfort remain poorly defined. Recent research demonstrates that extracellular ATP released during tissue damage activates P2X7 receptors, which subsequently triggers a robust and sustained increase in secreted phosphoprotein 1 (SPP1) expression primarily within reactive microglia. This microglia-derived SPP1 acts through an autocrine integrin β1 (ITGB1) signaling loop to maintain a persistent, chemokine-rich…
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