1062-Tuning STAT Signaling with Trikine Immunotherapeutics
This research introduces Trikines, a novel class of engineered cytokine ligands designed to improve cancer immunotherapy by precisely reconfiguring cellular signaling. Unlike natural cytokines that typically pair two receptor chains, Trikines recruit a third receptor chain to create a three-chain complex, allowing for the simultaneous activation of specific STAT proteins like pSTAT3 and pSTAT5. This "mix-and-match" approach enables scientists to customize immune cell behavior, such as enhancing T cell stemness and survival while reducing the exhaustion often caused by traditional treatments…
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