Latest / The Natural Alternative - with Madonna Guy
355: Oxalates, Histamines & GLP1 GLP2 & GIP Resistance: How Plant Toxins Disrupt Signalling & Metabolism
Madonna’s recap highlights a powerful but often overlooked concept: plant‑derived irritants like oxalates and histamines can inflame the gut lining, activate mast cells, and injure L cells—the very cells responsible for producing GLP‑1, GLP‑2, and GIP. When these cells are stressed or damaged, incretin release becomes blunted, nutrient sensing becomes unreliable, and the gut becomes more permeable. This creates a state of functional incretin resistance, where the body technically produces incretins but cannot use them effectively. The downstream effects—poor satiety, unstable blood sugar…
The skinny
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