278-Immune Architecture in the Second-Trimester Fetus
The paper present a comprehensive single-cell immune atlas comparing immune architecture and activity in second-trimester fetuses and adults across multiple organs. This research challenges the idea of fetal immune quiescence by uncovering widespread memory and activated T cells, alongside evidence of T-cell receptor (TCR) clonal sharing across various organs, including barrier sites. The study identifies specific immune tolerance mechanisms in the fetus, notably involving ARG1+ neutrophils and the PTGES3-PTGER4 signaling pathway, which actively suppress T cell activation. Furthermore, it…
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