839-Perinatal Pig Brain Multi-Omics

Paper Talk · Apr 22, 2026 · 21m

This research established a comprehensive multi-omics atlas of the perinatal brain using Bama miniature pigs to bridge critical gaps in human neurodevelopmental knowledge. By analyzing transcriptomes and proteomes across various brain regions and time points, the study identified a pivotal developmental transition occurring between embryonic days 94 and 104. The authors demonstrated that pigs serve as a superior large-animal model compared to rodents, mirroring primate-specific processes like gliogenesis and synaptic refinement. Their findings revealed a "rise-and-fall" pattern of regional…