893-Molecular and Spatial Signatures of Mouse Brain Aging
This research details the creation of a high-resolution cell atlas to track how the mouse brain changes during the aging process. By utilizing advanced single-cell transcriptomics and spatial imaging, scientists mapped the molecular architecture of the frontal cortex and striatum across various life stages. The findings indicate that non-neuronal cells, such as glia and immune cells, experience much more significant alterations in state and gene expression than neurons do. Specifically, the subcortical white matter was identified as a primary site for age-related inflammation and cellular…
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