793-Hypoxia-TAM Dynamics in Glioblastoma

Paper Talk · Apr 14, 2026 · 23m

This research identifies a specialized group of monocyte-derived tumor-associated macrophages (Mo-TAMs), termed Hypoxia-TAMs, which congregate in the necrotic regions of glioblastoma. Using single-cell transcriptomics and spatial analysis, the authors discovered that these cells are reprogrammed by the tumor's oxygen-depleted environment to secrete adrenomedullin (ADM). This protein destabilizes vascular integrity by disrupting endothelial junctions, resulting in leaky blood vessels that prevent effective drug delivery. The study demonstrates that using an ADM antagonist can normalize tumor…