658-Calcium Imaging in CA1 Dendrites
This article introduces a novel 3D real-time motion correction (3D-RTMC) platform designed for high-speed, two-photon voltage and calcium imaging in the brains of active mice. By using nearby neurons as stable reference points, the researchers successfully captured the rapid electrical dynamics of hippocampal CA1 dendrites that were previously obscured by physical movement. Their findings demonstrate that action potentials attenuate significantly as they travel further from the cell body, though somatic bursts propagate more effectively than single spikes. The study also reveals that the…
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