263-Proinflammatory Niches Drive Lung cancer Initiation

Paper Talk · Nov 24, 2025 · 13m

This article describes research using multimodal spatial-omics to investigate the progression of lung precursor lesions to lung adenocarcinoma (LUAD). The authors reveal that KRT8-high alveolar intermediate cells (KACs), or reactive pneumocytes (RPII), are early precursors in LUAD development, often residing in epithelial-proinflammatory niches enriched with IL-1β–IL1R1 signaling. Through spatial transcriptomics and single-cell analysis of human and mouse samples, the study demonstrates that these proinflammatory niches are stage-specific and more prevalent in premalignant phases. Crucially…