737-The Interoceptive of Age-Associated Cognitive Decline

Paper Talk · Apr 3, 2026 · 16m

This research identifies a specific gut-brain pathway that accelerates age-related cognitive decline through the disruption of internal sensory signaling. Scientists discovered that the accumulation of the bacterium Parabacteroides goldsteinii in older mice triggers peripheral inflammation, which subsequently impairs the function of vagal sensory neurons. This interoceptive dysfunction prevents the brain from receiving necessary signals, leading to diminished hippocampal activity and significant memory loss. The study demonstrates that these cognitive deficits can be transmitted to young mice…