1093-Hyocholic Acids: Metabolic Mediators of Immunity
This research explores how hyocholic acids (HCAs), a primary bile acid produced by the fetal liver, act as a vital immunological buffer during early development. While HCAs are scarce in adults, they dominate neonatal meconium and serum, playing a central role in establishing immune tolerance by promoting anti-inflammatory Treg cells while suppressing pro-inflammatory Th17 cells. This metabolic window facilitates the healthy colonization of beneficial gut microbiota, such as Bifidobacterium, while protecting infants from pathogens and gastrointestinal disorders like necrotizing enterocolitis…
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