297-cSplotch: Inferring Cell-Type-Specific Spatial profile
The source details the creation of a comprehensive spatiotemporal atlas of the mouse colon to characterize the complex tissue and molecular changes that occur during aging across various anatomical regions and life stages. This extensive resource was built by integrating data from roughly 1,500 tissue sections analyzed by spatial transcriptomics (ST) and over 400,000 profiles gathered through single nucleus RNA-sequencing (snRNA-seq). To synthesize this multimodal data, the authors developed a novel hierarchical Bayesian model called cSplotch, which accurately infers cell-type-specific gene…
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