436-Acute Exercise and the Human Immune Cell Proteome

Paper Talk · Jan 26, 2026 · 15m

This research study presents a comprehensive proteomic analysis of human immune cells following acute physical activity. By comparing high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE), researchers discovered that intense movement triggers more significant rewiring of immune cell pathways related to activation and effector function. The study utilized mass spectrometry and flow cytometry to identify over 6,000 proteins, finding that these molecular changes occur regardless of identical cell mobilization patterns between the two exercise types…