Mirtazapine and Bupropion – Test Prep and Practice Pearls

Real Life Pharmacology - Pharmacology Education for Health Care Professionals · May 28, 2026 · 14m

Mirtazapine is a unique antidepressant often chosen when depression occurs alongside insomnia or poor appetite. Its antihistamine activity makes it sedating, particularly at lower doses, and it commonly increases appetite and weight. Unlike many SSRIs, mirtazapine has a lower risk of sexual dysfunction and gastrointestinal side effects because it blocks 5-HT2 and 5-HT3 receptors. It is frequently dosed at bedtime and can be especially useful in older adults or medically ill patients who need both mood improvement and help with sleep or weight gain.

Bupropion is an activating antidepressant…