150-Spatial transcriptomic plasticity in pancreatic cancer

Paper Talk · Oct 20, 2025 · 20m

This paper details a spatial transcriptomic analysis of metastatic pancreatic cancer across primary tumors and various metastatic sites (liver, lung, and peritoneum) from 13 rapid-autopsy patients. The research focuses on mapping the transcriptomic heterogeneity of cancer cells, clonal evolution, and the tumor microenvironment (TME) with high resolution. Key findings include discernible shifts in cancer-cell lineage states as the tumor metastasizes to different organs, particularly noting a pronounced difference between liver (basal-like predominant) and lung (classical predominant)…