1349-The MDK-Targeted EV-Photoimmunotherapy Platform
This research article details the development of Ce6@D4-EV, an innovative nanoplatform that utilizes extracellular vesicles to deliver targeted photoimmunotherapy to dense solid tumors. By targeting the protein Midkine (MDK), these engineered vesicles accumulate specifically within the tumor microenvironment, where light activation triggers the destruction of cancer cells and the reprogramming of cancer-associated fibroblasts. This process successfully reduces the extracellular matrix barriers, improves blood flow, and alleviates hypoxia, transforming a resistant environment into one more…
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