Dr. Hope Rugo & Dr. Rebecca Shatsky - Earlier ESR1 Detection & Oral SERDs in Metastatic Breast Cancer

Community Health Media · May 8, 2026 · 27m

Can earlier ESR1 mutation detection help delay progression and preserve quality of life? In this episode of CHM Conversations, Dr. Hope Rugo and Dr. Rebecca Shatsky discuss the evolving role of oral SERDs and ctDNA monitoring in HR+ mBC.

The conversation centers on the SERENA-6 trial and the strategy of identifying ESR1 mutations before radiographic progression. Dr. Rugo and Dr. Shatsky explore how intervening earlier with camizestrant—while maintaining the CDK4/6 inhibitor backbone—may prolong progression-free survival and delay the transition to more intensive chemotherapy or ADCs.

The…