Nearly Half of Depression Patients Fail to Respond to Antidepressants

Epoch Reports · Apr 5, 2025 · 6m

A new study has found a critical challenge in mental health treatment: 48 percent of depression patients do not respond to multiple antidepressant medications.

This phenomenon, known as treatment-resistant depression (TRD), is generally defined as depression that remains after a patient has tried two different types of antidepressant medication. Currently, there are limited guidelines available for managing TRD.

Published in the British Journal of Psychiatry, the study sheds light on a condition that leaves patients increasingly vulnerable.

Read the Original Report here.

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