1067-Building Organ Intrinsic Nervous Systems

Paper Talk · Jun 2, 2026 · 21m

This research explores how organ intrinsic nervous systems (OINSs), such as those in the heart, lungs, and gut, develop their unique structures and identities from a shared embryonic origin. Using 3D imaging and single-cell sequencing, the study reveals a "dual logic" where neural crest cell migratory lineages establish the initial spatial framework while local organ environments dictate final molecular identities. Specifically, neurons in the heart and lungs derive from Schwann cell precursors that form localized clusters, whereas enteric and pancreatic neurons arise from migratory lineages…