974-Atlas of First Trimester Human Amnion Development

Paper Talk · May 15, 2026 · 19m

This study presents a comprehensive atlas of the human amnion during the first trimester of pregnancy using single-cell transcriptomics. Researchers identified six primary cell types across the epithelial, mesenchymal, and macrophage lineages, uncovering how these populations interact through pathways like BMP4 and TGF-β to drive tissue growth. The data highlights significant cellular remodeling, including transitions where cells shift from epithelial states into mesenchymal or immune roles. Furthermore, the authors compared in vivo human data with non-human primates and stem cell-derived…