934-Plaque-Associated Microglia in Alzheimer’s Disease
This research investigates the complex spatial and functional dynamics of microglia within mouse models of Alzheimer’s disease. By distinguishing between plaque-associated microglia (PAM) and non-plaque-associated microglia (non-PAM), the study reveals that these cells exist in distinct states defined by their proximity to amyloid deposits. High-resolution mapping demonstrates that non-PAM are highly versatile cells that eventually transition into clonally expanding PAM as the disease progresses. Furthermore, the authors show that environmental factors, such as gut microbiota and peripheral…
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