1258-Cellular Differentiation Trajectories in Gastric Antrum
This study utilizes single-cell RNA profiling and spatial transcriptomics to map how epithelial cells transform during the progression of intestinal-type gastric cancer. By examining stages from chronic inflammation to early malignancy, researchers identified that progenitor cells (PCs) serve as the primary source for various cell lineages in the gastric antrum. During intestinal metaplasia, both PCs and gland mucous cells undergo reprogramming to become intestinal-like stem cells, which then differentiate into mature enterocytes. Furthermore, the analysis highlights KIAA0101+PRAP1+…
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