1565-Spatial Remodeling of Skin Cancer Microenvironment
This scientific study utilizes spatial multi-omics and single-cell sequencing to investigate why immunosuppressed patients with non-melanoma skin cancer suffer from worse clinical outcomes. The researchers discovered that while the overall types of immune cells remain similar between patients, their spatial organization and functional interactions are significantly disrupted in the immunosuppressed state. Specifically, these high-risk patients exhibit a reduction in intratumoral macrophages and a less diverse T cell repertoire, which likely hinders the body's ability to fight the tumor. By…
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