984-Restrictions of Cell Competition in Mosaic Gastruloids

Paper Talk · May 17, 2026 · 20m

This research utilizes mouse gastruloids as a three-dimensional model to investigate cell competition during early mammalian development. By introducing p53-deficient supercompetitor cells into wild-type populations, the authors demonstrate that even a tiny fraction of these aggressive cells can trigger mitochondrial apoptosis in their neighbors. The study identifies a specific temporal window—the transition from pluripotency to early gastrulation—where this competitive selection is most active. Unlike two-dimensional cultures that rely on resource limitation, this 3D embryonic model reveals…