672-Plexin-B2-Mediated Glioblastoma Invasion Tracks

Paper Talk · Mar 21, 2026 · 25m

This research investigates how glioblastoma (GBM), an aggressive brain cancer, transitions from a localized mass to a lethal, infiltrative growth pattern. Using mouse models and human samples, scientists discovered that microglia—the brain's immune cells—are mobilized in "oncofields" ahead of the tumor to create organized invasion tracks. These immune cells transform into oncostreams, which are longitudinal structures that physically guide collective cancer cell migration and restructure the extracellular matrix. A key molecular finding identifies the plexin-B2 receptor in immune cells as the…