1083-CRISPRa Mapping of Cancer Glycome and Immune Evasion
This study utilizes CRISPR activation (CRISPRa) screening to identify the genetic drivers behind cancer glycome remodeling, a process where tumors alter their surface sugars to evade the immune system. By forcing the overexpression of thousands of genes, the researchers mapped how specific enzymes and "professional ligands" like CD44 and CSPG4 facilitate binding to inhibitory Siglec receptors on immune cells. Their findings reveal that Siglec-10 primarily interacts with N-linked sialoglycans rather than exclusively binding to CD24, as previously thought. The study also highlights the…
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