Micro 61: Antifungal Agents
This episode explores antifungal pharmacology within the structural complexity of eukaryotic pathogens. Drawing from Murray’s Chapter 61, it examines how therapeutic strategy is shaped by the similarities between fungal and human cells.
Because fungi are eukaryotic, drug selectivity must target features unique to fungal biology. The episode organises antifungal agents by mechanism:
* Polyenes (e.g., amphotericin B) - bind ergosterol and disrupt membranes
* Azoles - inhibit ergosterol synthesis
* Echinocandins - inhibit β-glucan synthesis in the fungal cell wall
* Flucytosine - interferes with…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.